Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.54 |
| ▸ | PDE2A | O00408 | 2/20 | 0.54 |
| ▸ | PDE1A | P54750 | 1/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11006142 | 0.84 | PDE3B (0.52) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10548815 | 0.82 | KCNJ1 (0.44) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL17185938 | 0.80 | PDE3B (0.53) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7425735 | 0.80 | PDE3B (0.52) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7404429 | 0.78 | PDE3B (0.47) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7404431 | 0.78 | PDE3B (0.47) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7381531 | 0.77 | CYP11B2 (0.52) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7282912 | 0.76 | PDE3B (0.66) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7303663 | 0.76 | PDE3B (0.48) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10833710 | 0.76 | PDE3B (0.66) | PDE3BPDE3APDE2APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0102227-B1 | 2(1H)-PYRIDINONES, USEFUL AS CARDIOTONIC AGENTS, AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1989-05-03 | — | — | EP | disclosed |
| US-4717730-A | HYPOTENSIVE AND CARDIOTONIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1988-01-05 | — | — | US | disclosed |
| US-4607037-A | Cardiotonic 2(1H)-pyridinones | WARNER-LAMBERT COMPANY (US) | 1986-08-19 | — | — | US | disclosed |
| US-4599332-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1986-07-08 | — | — | US | disclosed |
| EP-0145450-A2 | 6- [2-[4-(1H-imidazol-1-yl)phenyl]-alkylene and alkylenyl]-3(2H)-pyridazinones, the 4,5-dihydro- pyridazinone derivatives thereof, and a process for the preparation thereof | WARNER-LAMBERT COMPANY (US) | 1985-06-19 | — | — | EP | disclosed |
| US-4503061-A | Substituted phenyl-pyridinones as cardiotonic agents | WARNER-LAMBERT COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0102227-A2 | 2(1H)-pyridinones, useful as cardiotonic agents, and their production | WARNER-LAMBERT COMPANY (US) | 1984-03-07 | — | — | EP | disclosed |