Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 7/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10801856 | 0.94 | NPSR1 (0.39) | SSTR5CYP2D6 | |
| SCHEMBL10548471 | 0.93 | MEN1 (0.39) | TP53 | |
| SCHEMBL1151613 | 0.88 | SSTR5 (0.56) | KCNH2NR4A2SSTR5HRH1TACR2 | |
| SCHEMBL10798744 | 0.87 | SLC6A9 (0.44) | CYP2D6TP53 | |
| SCHEMBL10549709 | 0.87 | MAPT (0.38) | HRH1 | |
| SCHEMBL9807304 | 0.85 | EED (0.54) | KCNH2NR4A2SSTR5HRH1TACR2 | |
| SCHEMBL10552831 | 0.85 | KCNH2 (0.47) | KCNH2NR4A2SSTR5HRH1TACR2 | |
| SCHEMBL10548825 | 0.84 | KCNH2 (0.42) | KCNH2NR4A2SSTR5HRH1TACR2 | |
| SCHEMBL9739865 | 0.84 | SSTR5 (0.54) | KCNH2NR4A2SSTR5HRH1TACR2 | |
| SCHEMBL11470118 | 0.80 | SSTR5 (0.60) | KCNH2NR4A2SSTR5HRH1TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |