SLC6A9 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Hydrochloric Acid (SCHEMBL375237)	1.00	20/20
SCHEMBL427134	1.00	20/20
Bitopertin (SCHEMBL561853)	1.00	20/20
SCHEMBL562102	1.00	20/20
Bitopertin (SCHEMBL562490)	1.00	20/20
SCHEMBL562797	1.00	20/20
SCHEMBL562110	0.81	20/20
SCHEMBL562007	0.78	20/20
SCHEMBL562045	0.77	20/20
SCHEMBL375306	0.75	20/20
SCHEMBL606260	0.75	20/20
SCHEMBL605473	0.72	20/20
SCHEMBL604587	0.71	20/20
SCHEMBL606040	0.71	20/20
SCHEMBL604295	0.66	20/20
SCHEMBL604080	0.63	20/20
SCHEMBL606121	0.61	20/20
SCHEMBL604499	0.60	20/20
Hydrochloric Acid (SCHEMBL605880)	0.60	20/20
SCHEMBL380455	0.57	20/20

Clinical trials — most relevant to SLC6A9 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Salt Loading and Thiazide Intervention Study	PHASE4	COMPLETED
Effect of the Use of Dapagliflozin in Patients With Refractory Heart Failure	PHASE4	RECRUITING
Febuxostat, Blood Pressure and the Intrarenal Renin-Angiotensin System (RAS)	PHASE4	COMPLETED
Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study	PHASE4	RECRUITING
SGLT-2 Inhibitor Empagliflozin Effects on Appetite and Weight Regulation.	PHASE4	COMPLETED
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD	PHASE3	COMPLETED
Short and Intermediate Term Effect of Dapagliflozin on Left Ventricular Remodeling in Anterior STEMI Patients	PHASE3	UNKNOWN
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia	PHASE1/PHASE2	RECRUITING
GlyT-1 Inhibitor Treatment for Refractory Schizophrenia	PHASE2	COMPLETED
Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders	PHASE2	COMPLETED
Evaluating Safe Ketone Thresholds To Minimise Ketosis in People With Type 1 Diabetes Using Dapagliflozin	PHASE2	NOT_YET_RECRUITING
D-amino Acid Oxidase Inhibition (DAAOI-1) add-on Treatment for Chronic Schizophrenia	PHASE2	COMPLETED
Effect of Sarcosine on Symptomatology, Quality of Life, Oxidative Stress and Glutamatergic Parameters in Schizophrenia	PHASE2	COMPLETED
N-acetylcysteine (NAC) for Improving Cognitive Dysfunction in Schizophrenia	PHASE1	COMPLETED
Role of Metal Ion Transporter ZIP8 in Alcohol-Related Behaviors	PHASE1	RECRUITING
Effect of, OAT3, on the Renal Secretion of Cefotaxime	PHASE1	COMPLETED
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters	EARLY_PHASE1	COMPLETED
Mapping Brain Glutamate in Humans: Sex Differences in Cigarette Smokers	nan	COMPLETED
POTASSIUM-RICH SALT SUBSTITUTES IN KIDNEY TRANSPLANT RECIPIENTS	nan	NOT_YET_RECRUITING
Lithium Countertransport and Blood Pressure In CARDIA and TOMHS	nan	COMPLETED
CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve Sprouting	nan	UNKNOWN
Acute Glycine Pharmacodynamic Study	nan	COMPLETED
Oxalate and Citrate in Humans - Response to Citrate	nan	RECRUITING
Renal Transporters After Renal Transplantation	nan	UNKNOWN
A Study of Cases with Abnormal Serum Ammonia in Neonate and Children Attending Assiut University Children Hospital	nan	NOT_YET_RECRUITING
Sodium Transport: Genetics and Hypertension	nan	COMPLETED
Stem Cell Study of Genetics and Drug Addiction	nan	COMPLETED
SLC13A5 Deficiency Natural History Study - United States Only	nan	ENROLLING_BY_INVITATION
Insulin Detemir in Obesity Management	nan	ACTIVE_NOT_RECRUITING
TRANSEURO Open Label Transplant Study in Parkinson's Disease	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SLC6A9 binder may also engage these)

Protein	Name	Similarity
P28571	—	1.000	P28571 →
P31661	—	0.997	P31661 →
P28570	—	0.997	P28570 →
O88575	—	0.997	O88575 →
Q61327	—	0.997	Q61327 →
P23977	—	0.997	P23977 →
SLC6A4	Sodium-dependent serotonin transporter	0.997	landscape →
P28572	—	0.997	P28572 →
O18875	—	0.997	O18875 →
Q9MYX0	—	0.997	Q9MYX0 →
P31649	—	0.996	P31649 →
P48029	—	0.996	P48029 →
Q761V0	—	0.996	Q761V0 →
Q9GJT6	—	0.996	Q9GJT6 →
P31652	—	0.996	P31652 →
P31646	—	0.995	P31646 →
SLC6A11	Sodium- and chloride-dependent GABA transporter 3	0.995	landscape →
SLC6A13	Sodium- and chloride-dependent GABA transporter 2	0.995	landscape →
Q28039	—	0.995	Q28039 →
P27922	—	0.994	P27922 →
P51143	—	0.994	P51143 →
Q9MZ34	—	0.994	Q9MZ34 →
SLC6A19	Sodium-dependent neutral amino acid transporter B(0)AT1	0.994	landscape →
P31647	—	0.994	P31647 →
SLC6A6	Sodium- and chloride-dependent taurine transporter	0.994	landscape →
Q96N87	—	0.994	Q96N87 →
Q5R6J1	—	0.993	Q5R6J1 →
Q08469	—	0.993	Q08469 →
SLC6A5	Sodium- and chloride-dependent glycine transporter 2	0.993	landscape →
O35316	—	0.993	O35316 →