Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.33 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | PDE6D | O43924 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE6A | P16499 | 1/20 | 0.32 |
| ▸ | PDE6G | P18545 | 1/20 | 0.32 |
| ▸ | PDE6B | P35913 | 1/20 | 0.32 |
| ▸ | PDE6C | P51160 | 1/20 | 0.32 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3452348 | 0.85 | BRD4 (0.39) | BRD4NPC1PDE10ABRD2BRD3 | |
| SCHEMBL3452342 | 0.85 | BRD4 (0.39) | BRD4NPC1PDE10ABRD2BRD3 | |
| SCHEMBL3452346 | 0.85 | BRD4 (0.39) | BRD4NPC1PDE10ABRD2BRD3 | |
| SCHEMBL1929365 | 0.82 | BRD4 (0.46) | BRD4NPC1PDE10ABRD2BRD3 | |
| SCHEMBL5506152 | 0.82 | BRD4 (0.46) | BRD4NPC1PDE10ABRD2BRD3 | |
| SCHEMBL3854400 | 0.77 | BRD4 (0.38) | BRD4NPC1PDE10ABRD2BRD3 | |
| SCHEMBL5506422 | 0.76 | NPC1 (0.43) | BRD4NPC1BRD2BRD3BRDT | |
| SCHEMBL11886698 | 0.76 | SYK (0.38) | BRD4NPC1P2RX7 | |
| SCHEMBL11886649 | 0.75 | ACE (0.43) | BRD4P2RX7 | |
| SCHEMBL1054889 | 0.75 | BRD4 (0.35) | BRD4NPC1BRD2BRD3BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110003791-A1 | Cyclized Derivatives as EG-5 Inhibitors | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003791-A1 | Cyclized Derivatives as EG-5 Inhibitors | CYP3A5, GDI2, HDAC5 | BRD4 2965/4885NPC1 191/4885PDE10A 187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.