Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 13/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 3/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10555473 | 0.83 | PDE3B (0.53) | PDE3BPDE3AMAPTHRH3 | |
| SCHEMBL16156994 | 0.82 | PDE3B (0.72) | PDE3BPDE3AALDH1A1KDM4EMAPT | |
| SCHEMBL16156986 | 0.82 | PDE3B (0.72) | PDE3BPDE3AALDH1A1KDM4EMAPT | |
| SCHEMBL7266778 | 0.79 | MAPT (0.61) | PDE3BPDE3AALDH1A1KDM4EMAPT | |
| SCHEMBL10548993 | 0.77 | PDE3B (0.54) | PDE3BPDE3AHRH3PDE4APDE4B | |
| SCHEMBL10553519 | 0.77 | PDE3B (0.54) | PDE3BPDE3AHRH3PDE4APDE4B | |
| SCHEMBL10549361 | 0.76 | PDE3B (0.50) | PDE3BPDE3AMAPTGPR119HRH3 | |
| SCHEMBL10517762 | 0.76 | GPR119 (0.51) | PDE3BPDE3AALDH1A1KDM4EMAPT | |
| SCHEMBL10517769 | 0.76 | PDE3B (0.55) | PDE3BPDE3AALDH1A1KDM4EMAPT | |
| SCHEMBL10553072 | 0.76 | PDE3B (0.50) | PDE3BPDE3AHRH3PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847251-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-11 | — | — | US | disclosed |
| EP-0255704-A2 | Pyridazinone derivatives, process for their preparation and their use as medicines | Roche Diagnostics GmbH (DE) | 1988-02-10 | — | — | EP | disclosed |