⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9617943 | 0.79 | — | — | |
| SCHEMBL466704 | 0.76 | — | — | |
| SCHEMBL2921901 | 0.76 | — | — | |
| SCHEMBL8162097 | 0.76 | — | — | |
| SCHEMBL5153807 | 0.76 | — | — | |
| SCHEMBL2928722 | 0.76 | — | — | |
| SCHEMBL6887964 | 0.76 | — | — | |
| SCHEMBL14113732 | 0.75 | TSHR (0.69) | — | |
| SCHEMBL168774 | 0.75 | TSHR (0.69) | — | |
| SCHEMBL17967786 | 0.74 | ALOX15 (0.71) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9526737-B2 | Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-12-27 | — | — | US | claimed |
| US-20110008297-A1 | OXYSTEROLS FOR ACTIVATION OF HEDGEHOG SIGNALING, OSTEOINDUCTION, ANTIADIPOGENESIS, AND WNT SIGNALING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-13 | — | — | US | claimed |
| EP-2231164-A1 | OXYSTEROLS FOR ACTIVATION OF HEDGEHOG SIGNALING, OSTEOINDUCTION, ANTIADIPOGENESIS, AND WNT SIGNALING | The Regents of the University of California (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009073186-A1 | OXSTEROLS FOR ACTIVATION OF HEDGEHOG SIGNALING, OSTEOINDUCTION, ANTIADIPOGENESIS, AND WNT SIGNALING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-11 | — | — | WO | claimed |
| US-11690834-B2 | Composition, uses, and methods of treating spinal disc degeneration through sonic hedgehog signaling pathway | NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY (US) | 2023-07-04 | — | — | US | disclosed |
| US-9526737-B2 | Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-12-27 | — | — | US | disclosed |
| US-20110008297-A1 | OXYSTEROLS FOR ACTIVATION OF HEDGEHOG SIGNALING, OSTEOINDUCTION, ANTIADIPOGENESIS, AND WNT SIGNALING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-13 | — | — | US | disclosed |
| EP-2231164-A1 | OXYSTEROLS FOR ACTIVATION OF HEDGEHOG SIGNALING, OSTEOINDUCTION, ANTIADIPOGENESIS, AND WNT SIGNALING | The Regents of the University of California (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009073186-A1 | OXSTEROLS FOR ACTIVATION OF HEDGEHOG SIGNALING, OSTEOINDUCTION, ANTIADIPOGENESIS, AND WNT SIGNALING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-11 | — | — | WO | disclosed |