Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 10/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6508596 | 0.85 | NR1H2 (0.39) | NR1H2GABRG2GABRB3GABRA5NR1H3 | |
| SCHEMBL21146832 | 0.84 | GABRG2 (0.43) | NR1H2GABRG2GABRB3GABRA5NR1H3 | |
| SCHEMBL10552835 | 0.83 | NR1H2 (0.40) | NR1H2GABRG2GABRB3GABRA5NR1H3 | |
| SCHEMBL18437161 | 0.82 | NR1H2 (0.37) | NR1H2GABRG2GABRB3GABRA5NR1H3 | |
| SCHEMBL18848182 | 0.82 | NR1H2 (0.40) | NR1H2GABRG2GABRB3GABRA5NR1H3 | |
| SCHEMBL4037148 | 0.82 | CYP2A6 (0.38) | NR1H2GABRG2GABRB3GABRA5NR1H3 | |
| SCHEMBL27108521 | 0.81 | NR1H2 (0.46) | NR1H2GABRG2GABRB3GABRA5NR1H3 | |
| SCHEMBL4725709 | 0.80 | NR1H2 (0.52) | NR1H2NR1H3 | |
| SCHEMBL4795293 | 0.80 | NR1H2 (0.57) | NR1H2NR1H3 | |
| SCHEMBL20435588 | 0.80 | NR1H2 (0.36) | NR1H2GABRG2GABRB3GABRA5NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831144-A | 1H-pyrrolo [3,2-c]pyrrolidines protected in 1-position useful as intermediates | SANOFI (FR) | 1989-05-16 | — | — | US | claimed |
| US-4831032-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE, ISOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-16 | — | — | US | disclosed |
| US-4831144-A | 1H-pyrrolo [3,2-c]pyrrolidines protected in 1-position useful as intermediates | SANOFI (FR) | 1989-05-16 | — | — | US | disclosed |