GABRG2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL104133	0.66	20/20
SCHEMBL15406	0.61	20/20
Fipronil (SCHEMBL15088)	0.59	20/20
SCHEMBL41972	0.59	20/20
Fipronil (SCHEMBL44222)	0.59	20/20
Ethiprole (SCHEMBL27048)	0.56	20/20
SCHEMBL25897	0.51	20/20
SCHEMBL104346	0.68	19/20
SCHEMBL103712	0.67	19/20
SCHEMBL33214	0.52	19/20
SCHEMBL26584	0.51	19/20
Flumazenil (SCHEMBL79030)	1.00	16/20
Iomazenil (SCHEMBL41658)	0.71	12/20
SCHEMBL9107	0.56	12/20
SCHEMBL8532	1.00	11/20
Bretazenil (SCHEMBL124595)	1.00	10/20
SCHEMBL9035	0.56	10/20
SCHEMBL8632	0.54	10/20
SCHEMBL8670	0.57	9/20
SCHEMBL8856	0.53	9/20

Clinical trials — most relevant to GABRG2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Computational Assessment of GABA Receptor Modulation in PTSD	PHASE4	RECRUITING
Safety of Ramelteon in Elderly Subjects	PHASE4	COMPLETED
The Effects of Levetiracetam on Alcohol Dependent Subjects	PHASE4	COMPLETED
The Effect of Oral Baclofen and Botulinum Toxin Treatments in Hemiplegic Spasticity on the Nociceptive Flexor Reflex	PHASE4	COMPLETED
Evaluating the Safety of Acute Baclofen in Methadone-maintained Individuals With Opiate Dependence.	PHASE4	COMPLETED
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia	PHASE3	COMPLETED
Diazepam Trial in GAD65 Associated Epilepsy	PHASE1/PHASE2	WITHDRAWN
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia	PHASE2	COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia	PHASE2	COMPLETED
Effects of Direct Transcranial Current Stimulation on Central Neural Pain Processing in Fibromyalgia	PHASE1/PHASE2	COMPLETED
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome	PHASE2	RECRUITING
PET Imaging of Brain Peripheral Benzodiazepine Receptors	PHASE1	COMPLETED
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28	PHASE1	COMPLETED
MEG Study of Acute STX209 Effects in ASD	EARLY_PHASE1	COMPLETED
Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T	EARLY_PHASE1	UNKNOWN
Cenobamate Efficacy in Individuals With Autoimmune Epilepsy	nan	ENROLLING_BY_INVITATION
GABA Biomarkers in Dravet Syndrome	nan	RECRUITING
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy	nan	UNKNOWN
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.	nan	COMPLETED
Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain	nan	UNKNOWN
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory	nan	COMPLETED
GABRA2 and the Pharmacokinetics of Risk for Alcoholism (GPRA)	nan	COMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services	nan	UNKNOWN
Remifentanil and Remimazolam to Limit Patient Movement	nan	RECRUITING
Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy)	nan	UNKNOWN
Brain Changes in Patients With Focal Hand Dystonia	nan	COMPLETED
GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression	nan	COMPLETED
Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle	nan	COMPLETED
Functional Study of Inhibitory Neurotransmission in the Human Epileptic Brain.	nan	RECRUITING
Mechanisms of Human Plasticity in the Human System	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GABRG2 binder may also engage these)

Protein	Name	Similarity
P18508	—	1.000	P18508 →
P22723	—	1.000	P22723 →
P22300	—	1.000	P22300 →
Q5REA1	—	1.000	Q5REA1 →
P23574	—	1.000	P23574 →
P21548	—	1.000	P21548 →
Q9R0Y8	—	0.999	Q9R0Y8 →
GABRG1	Gamma-aminobutyric acid receptor subunit gamm	0.997	landscape →
P34904	—	0.976	P34904 →
P50571	—	0.967	P50571 →
P15431	—	0.967	P15431 →
GABRB1	Gamma-aminobutyric acid receptor subunit beta-1	0.967	landscape →
P24045	—	0.965	P24045 →
GABRB2	Gamma-aminobutyric acid receptor subunit beta-2	0.964	landscape →
P63137	—	0.964	P63137 →
P27681	—	0.963	P27681 →
P08220	—	0.962	P08220 →
P28473	—	0.962	P28473 →
GABRA6	Gamma-aminobutyric acid receptor subunit alpha-6	0.962	landscape →
D1LYT2	—	0.961	D1LYT2 →
P10064	—	0.960	P10064 →
P26049	—	0.958	P26049 →
GABRA3	Gamma-aminobutyric acid receptor subunit alpha-3	0.958	landscape →
P20236	—	0.957	P20236 →
P19969	—	0.956	P19969 →
P0C2W5	—	0.955	P0C2W5 →
P16305	—	0.954	P16305 →
P08219	—	0.953	P08219 →
P30191	—	0.953	P30191 →
P62813	—	0.953	P62813 →