Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | MC4R | P32245 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13638129 | 0.86 | KMT2A (0.71) | SIGMAR1KDM4EKMT2AMEN1MC4R | |
| SCHEMBL28851969 | 0.80 | KDM4E (0.59) | SIGMAR1KDM4EKMT2AMEN1MC4R | |
| SCHEMBL242970 | 0.79 | SIGMAR1 (1.00) | SIGMAR1KMT2AMC4RLMNAPOLB | |
| SCHEMBL1041303 | 0.79 | SIGMAR1 (1.00) | SIGMAR1KMT2AMC4RLMNAPOLB | |
| SCHEMBL576868 | 0.79 | SIGMAR1 (1.00) | SIGMAR1KMT2AMC4RLMNAPOLB | |
| SCHEMBL1415730 | 0.79 | SIGMAR1 (1.00) | SIGMAR1KMT2AMC4RLMNAPOLB | |
| SCHEMBL8188324 | 0.79 | SIGMAR1 (1.00) | SIGMAR1KMT2AMC4RLMNAPOLB | |
| SCHEMBL2489199 | 0.79 | SIGMAR1 (1.00) | SIGMAR1KMT2AMC4RLMNAPOLB | |
| SCHEMBL6661493 | 0.77 | SIGMAR1 (0.78) | SIGMAR1KDM4EKMT2AMEN1MC4R | |
| SCHEMBL1045589 | 0.77 | SIGMAR1 (0.78) | SIGMAR1KDM4EKMT2AMEN1MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4801706-A | ANTIARRHYTHMIA HYPOTENSIVE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-01-31 | — | — | US | disclosed |