Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 12/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.43 |
| ▸ | PDE4A | P27815 | 6/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9668887 | 0.86 | GPR119 (0.40) | SMN1; SMN2GPR119LMNAKDM4ENPC1 | |
| SCHEMBL9668467 | 0.85 | PDE3B (0.42) | SMN1; SMN2GPR119LMNAPDE3BPDE3A | |
| SCHEMBL9669040 | 0.84 | SMN1; SMN2 (0.60) | SMN1; SMN2GPR119LMNAKDM4ENPC1 | |
| SCHEMBL9670144 | 0.82 | PDE3B (0.45) | SMN1; SMN2GPR119LMNAPDE3BPDE3A | |
| SCHEMBL9667675 | 0.81 | KCNH2 (0.52) | SMN1; SMN2GPR119LMNAPDE3BPDE3A | |
| SCHEMBL10773509 | 0.81 | NPC1 (0.53) | SMN1; SMN2GPR119LMNAKDM4ENPC1 | |
| SCHEMBL9669200 | 0.81 | PDE3B (0.42) | SMN1; SMN2GPR119LMNAPDE3BPDE3A | |
| SCHEMBL9669065 | 0.80 | CYP19A1 (0.52) | SMN1; SMN2GPR119LMNAPDE3BPDE3A | |
| SCHEMBL9667556 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2GPR119LMNAKDM4EALDH1A1 | |
| SCHEMBL9667859 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2GPR119PDE3BPDE3APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4851406-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-25 | — | — | US | disclosed |