Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | ATG4B | Q9Y4P1 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.60 |
| ▸ | RELA | Q04206 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | CCR6 | P51684 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10552464 | 0.87 | MAPT (0.57) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL10415044 | 0.83 | SMN1; SMN2 (0.60) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL30763145 | 0.83 | SMN1; SMN2 (0.60) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL10556884 | 0.83 | MAPT (0.55) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL17136102 | 0.81 | HDAC6 (0.57) | NPC1RAB9ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL20302167 | 0.81 | P2RX7 (0.39) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL10414905 | 0.77 | KMT2A (0.75) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL10558445 | 0.76 | MAPT (0.64) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL10416326 | 0.76 | MAPT (0.69) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL10416381 | 0.75 | MAPT (0.68) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4886821-A | 2-pyridinecarbothioamides and pharmaceutical compositions comprising the same useful as anti ulcer agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-12-12 | — | — | US | claimed |
| US-4886821-A | 2-pyridinecarbothioamides and pharmaceutical compositions comprising the same useful as anti ulcer agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-12-12 | — | — | US | disclosed |