Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.73 |
| ▸ | CASP2 | P42575 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.64 |
| ▸ | NAAA | Q02083 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.61 |
| ▸ | FAAH | O00519 | 5/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.58 |
| ▸ | CNR1 | P21554 | 2/20 | 0.57 |
| ▸ | CNR2 | P34972 | 2/20 | 0.57 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.56 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.56 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.56 |
| ▸ | PPARG | P37231 | 2/20 | 0.56 |
| ▸ | PPARD | Q03181 | 2/20 | 0.56 |
| ▸ | PPARA | Q07869 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2639478 | 0.98 | EPHX2 (0.76) | EPHX2CASP2MEN1MAPTKMT2A | |
| SCHEMBL34460550 | 0.98 | EPHX2 (0.76) | EPHX2CASP2MEN1MAPTKMT2A | |
| SCHEMBL1301429 | 0.98 | EPHX2 (0.76) | EPHX2CASP2MEN1MAPTKMT2A | |
| SCHEMBL6277687 | 0.98 | EPHX2 (0.76) | EPHX2CASP2MEN1MAPTKMT2A | |
| SCHEMBL18972772 | 0.98 | EPHX2 (0.76) | EPHX2CASP2MEN1MAPTKMT2A | |
| SCHEMBL31272573 | 0.98 | EPHX2 (0.76) | EPHX2CASP2MEN1MAPTKMT2A | |
| SCHEMBL9830121 | 0.96 | EPHX2 (0.78) | EPHX2CASP2MEN1MAPTKMT2A | |
| SCHEMBL23052005 | 0.94 | EPHX2 (0.81) | EPHX2CASP2MEN1KMT2ANAAA | |
| SCHEMBL8044633 | 0.94 | EPHX2 (0.81) | EPHX2CASP2MEN1KMT2ANAAA | |
| SCHEMBL16013677 | 0.94 | EPHX2 (0.81) | EPHX2CASP2MEN1KMT2ANAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046319-A2 | CHOLECYSTOKININ-1 (CCK1) RECEPTOR ANTAGONISTS IN THE TREATMENT OF GASTROINTESTINAL AND RELATED DISORDERS | Rottapharm S.p.A. (IT) | 2009-04-15 | — | — | EP | claimed |
| WO-2007144345-A2 | CHOLECYSTOKININ-1 (CCK1) RECEPTOR ANTAGONISTS IN THE TREATMENT OF GASTROINTESTINAL AND RELATED DISORDERS | ROTTAPHARM S.P.A. (IT) | 2007-12-21 | — | — | WO | claimed |
| US-20070293574-A1 | CHOLECYSTOKININ-1(CCK1) RECEPTOR ANTAGONISTS IN THE TREATMENT OF GASTROINTESTINAL AND RELATED DISORDERS | ROTTAPHARM S.P.A. (IT) | 2007-12-20 | — | — | US | claimed |
| US-5602179-A | ANTISPASMODIC AGENTS | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 1997-02-11 | — | — | US | claimed |
| EP-0550899-B1 | Process for preparing derivatives of (R) 5-pentylamino-5-oxopentanoic acid with anticholecystokinin activity | ROTTA RESEARCH LAB (IT) | 1995-12-06 | — | — | EP | claimed |
| US-5391574-A | Antispasmodic agents | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 1995-02-21 | — | — | US | claimed |
| EP-0344184-B1 | DERIVATIVES OF (R) 5-PENTYLAMINO-5-OXOPENTANOIC ACID WITH ANTICHOLECYSTOKININ ACTIVITY | ROTTA RESEARCH LAB (IT) | 1993-11-24 | — | — | EP | claimed |
| EP-0550899-A1 | Process for preparing derivatives of (R) 5-pentylamino-5-oxopentanoic acid with anticholecystokinin activity | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 1993-07-14 | — | — | EP | claimed |
| US-5130474-A | For treatment of gastrointestinal disorders such as colitis, pancreatitis, antispastic agents and biliary diskinesia | ROTTA RESEARCH LABORATORIUM SPA (IT) | 1992-07-14 | — | — | US | claimed |
| EP-0272228-B1 | NEW DERIVATIVES OF 5-PENTYLAMINO-5-OXOPENTANOIC AND 4-PENTYLAMINO-4-OXO-BUTANOIC ACIDS WITH ANTAGONISTIC ACTIVITY TOWARDS CHOLECYSTOKININ AND A METHOD FOR THEIR PREPARATION | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 1992-02-05 | — | — | EP | claimed |
| EP-0344184-A1 | DERIVATIVES OF (R) 5-PENTYLAMINO-5-OXOPENTANOIC ACID WITH ANTICHOLECYSTOKININ ACTIVITY. | ROTTA RESEARCH LAB (IT) | 1989-12-06 | — | — | EP | claimed |
| WO-1988005774-A1 | DERIVATIVES OF (R) 5-PENTYLAMINO-5-OXOPENTANOIC ACID WITH ANTICHOLECYSTOKININ ACTIVITY | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 1988-08-11 | — | — | WO | claimed |
| EP-0272228-A2 | New Derivatives of 5-pentylamino-5-oxopentanoic and 4-pentylamino-4-oxo-butanoic acids with antagonistic activity towards cholecystokinin and a method for their preparation | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 1988-06-22 | — | — | EP | claimed |
| WO-2023150540-A1 | HYDROXAMIC ACID MACROCYCLIC AGENTS WITH PENDANT CHELATING MOIETIES AND COMPLEXES THEREOF | LUMIPHORE, INC. (US) | 2023-08-10 | — | — | WO | disclosed |
| WO-2022087317-A1 | THIOHYDROXYPYRIDINE CHELATES | LUMIPHORE, INC. (US) | 2022-04-28 | — | — | WO | disclosed |
| EP-3129350-B1 | MACROCYCLES | LUMIPHORE INC (US) | 2021-10-27 | — | — | EP | disclosed |
| US-4826878-A | New derivatives of 5-pentylamino-5-oxopentanoic and 4-pentylamino-4-oxobutanoic acids with antagonistic activity towards cholecystokinin | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 1989-05-02 | — | — | US | disclosed |
| WO-1988005774-A1 | DERIVATIVES OF (R) 5-PENTYLAMINO-5-OXOPENTANOIC ACID WITH ANTICHOLECYSTOKININ ACTIVITY | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 1988-08-11 | — | — | WO | disclosed |
| WO-1988005774-A1 | DERIVATIVES OF (R) 5-PENTYLAMINO-5-OXOPENTANOIC ACID WITH ANTICHOLECYSTOKININ ACTIVITY | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 1988-08-11 | — | — | WO | disclosed |
| EP-0272228-A2 | New Derivatives of 5-pentylamino-5-oxopentanoic and 4-pentylamino-4-oxo-butanoic acids with antagonistic activity towards cholecystokinin and a method for their preparation | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 1988-06-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293574-A1 | CHOLECYSTOKININ-1(CCK1) RECEPTOR ANTAGONISTS IN THE TREATMENT OF GASTROINTESTINAL AND RELATED DISORDERS | CCKAR, CCKBR, GRPR | EPHX2 2699/4885CASP2 2645/4885MEN1 1368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.