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CCKBR

Gastrin/cholecystokinin type B receptor · P32239 · CCKBR on Sugi Atlas →

82,754 patent compounds predicted against CCKBR, 52,118 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL194796 SCHEMBL194796 0.65 20/20
SCHEMBL641898 SCHEMBL641898 0.69 18/20
SCHEMBL642001 SCHEMBL642001 0.66 18/20
Ceruletide Ceruletide (SCHEMBL511740) 0.62 18/20
SCHEMBL641924 SCHEMBL641924 0.83 17/20
SCHEMBL641824 SCHEMBL641824 0.70 17/20
SCHEMBL641964 SCHEMBL641964 0.68 17/20
SCHEMBL642034 SCHEMBL642034 0.67 17/20
SCHEMBL642023 SCHEMBL642023 0.66 17/20
SCHEMBL642107 SCHEMBL642107 0.63 17/20
SCHEMBL184846 SCHEMBL184846 0.59 17/20
Sincalide Sincalide (SCHEMBL122365) 1.00 16/20
Devazepide Devazepide (SCHEMBL148766) 1.00 16/20
SCHEMBL642047 SCHEMBL642047 0.91 16/20
SCHEMBL641790 SCHEMBL641790 0.75 16/20
SCHEMBL641913 SCHEMBL641913 0.75 16/20
SCHEMBL641781 SCHEMBL641781 0.69 16/20
SCHEMBL640672 SCHEMBL640672 0.68 16/20
SCHEMBL641975 SCHEMBL641975 0.68 16/20
Ceruletide Ceruletide (SCHEMBL122757) 0.66 16/20

Clinical trials — most relevant to CCKBR by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Effect of the GLP-1 Analogue Exenatide on Type 2 Diabetes in CNS and Heart During Hyperglycemia Assessed by PET PHASE2/PHASE3COMPLETED
Effect of GLP-1 on Glucose Metabolism in CNS Assessed by PET PHASE2/PHASE3COMPLETED
Inhibition of Food Intake in Response to Oral GLP-1 and Peptide YY3-36 PHASE1/PHASE2COMPLETED
MITIGATE-NeoBOM: A Study to Evaluate 68Ga- NeoBOMB1 in Patients With Advanced TKI-treated GIST Using PET/CT PHASE1/PHASE2COMPLETED
Gastrointestinal Sensorimotor Dysfunctions in Diabetes Mellitus PHASE2COMPLETED
Radiolabelled CCK-2/Gastrin Receptor Analogue for Personalized Theranostic Strategy in Advanced MTC PHASE1COMPLETED
Safety, Tolerability and Pharmacokinetics of Single Rising Doses of YF476, a Gastrin Antagonist, in Healthy Men PHASE1COMPLETED
Effect of Single Doses of YF476 on Stomach Acidity Compared With Ranitidine and Placebo in Fasted and Fed States PHASE1COMPLETED
Effect of Repeated Doses of YF476, Omeprazole and Placebo on Stomach Acidity in Healthy Volunteers PHASE1COMPLETED
Intestinal Glucagon-like Peptide-1 (GLP-1) and the Physiological Role in Eating in Humans PHASE1COMPLETED
Effect of Repeated Doses of YF476 on Stomach Acidity PHASE1COMPLETED
Effect of Netazepide on Omeprazole-induced Changes in Chromogranin A and Gastrin PHASE1COMPLETED
Gastric Activity and Gastrointestinal Peptides in Patients With Functional Dyspepsia nanCOMPLETED
Enteroendocrine Cells Before and After Sleeve Gastrectomy nanCOMPLETED
Investigation of Acute Physiological Effects of Aspiration Therapy nanCOMPLETED
Dietary Carbohydrate and GERD in Veterans nanCOMPLETED
Symptom Evaluation After Cessation of a Proton Pump Inhibitor in Healthy Volunteers nanCOMPLETED
Hormone Release and Stomach Disturbances in People With Binge Eating Disorder nanCOMPLETED
Nutritional Management of Acute and Chronic Enterocutaneous Fistulae nanUNKNOWN
-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans. nanCOMPLETED
The Effect of Exogenous Glucagon-like Peptide 2 on Cholecystokinin-induced Gallbladder Emptying nanCOMPLETED
Longitudinal Analysis of Amylin Levels in Migraine Patients Undergoing an Anti- CGRP/CGRPr Treatment nanNOT_YET_RECRUITING
Regulation of Fat-stimulated Neurotensin Secretion in Healthy Subjects nanCOMPLETED
Impact of Neuropathy on the Risk of Semaglutide-Induced Gastric Retention nanNOT_YET_RECRUITING
The Effect of Sleeve Gastrectomy on Post-prandial Serum Bile Acids nanCOMPLETED
Lifestyle Intervention in Preparation for Pregnancy (LIPP) nanCOMPLETED
Gastrin, Anti-helicobacter Pylori and Pepsinogen Diagnostic Accuracy Study nanNOT_YET_RECRUITING
The Effects of GLP-1 Receptor Agonists on Chemosensory Function and Ingestive Behavior nanCOMPLETED
The Role of Estradiol and Progesterone on Appetite Regulation and Energy Balance nanRECRUITING
CCK1R Function in Patient Leukocytes nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a CCKBR binder may also engage these)

ProteinNameSimilarity
P30796 — 1.000 P30796 →
P30553 — 1.000 P30553 →
P30552 — 0.999 P30552 →
P46627 — 0.998 P46627 →
A0A287A2K5 — 0.998 A0A287A2K5 →
P79266 — 0.997 P79266 →
P56481 — 0.994 P56481 →
P33533 — 0.949 P33533 →
P79292 — 0.945 P79292 →
F1MV99 — 0.944 F1MV99 →
Q9JI35 — 0.944 Q9JI35 →
MLNR Motilin receptor 0.943 landscape →
P32300 — 0.942 P32300 →
P30938 — 0.942 P30938 →
Q9QYN8 — 0.940 Q9QYN8 →
P58406 — 0.940 P58406 →
OPRD1 Delta-type opioid receptor 0.939 landscape →
O08858 — 0.938 O08858 →
HRH3 Histamine H3 receptor 0.937 landscape →
P35377 — 0.936 P35377 →
SSTR5 Somatostatin receptor type 5 0.934 landscape →
Q49LX5 — 0.933 Q49LX5 →
SSTR1 Somatostatin receptor type 1 0.932 landscape →
Q5D0K2 — 0.930 Q5D0K2 →
OPRL1 Nociceptin receptor 0.929 landscape →
P30873 — 0.928 P30873 →
SSTR4 Somatostatin receptor type 4 0.927 landscape →
P30937 — 0.926 P30937 →
P47748 — 0.926 P47748 →
P28646 — 0.925 P28646 →