Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10555202 | 0.88 | SIGMAR1 (0.54) | SIGMAR1OPRM1OPRK1MAOAMAOB | |
| SCHEMBL530072 | 0.79 | SIGMAR1 (0.70) | SIGMAR1MAOAMAOBHTR1AHTR1D | |
| SCHEMBL528725 | 0.78 | SIGMAR1 (0.69) | SIGMAR1MAOAMAOBHTR1ACYP19A1 | |
| SCHEMBL13242848 | 0.78 | SIGMAR1 (0.69) | SIGMAR1MAOAMAOBHTR1ACYP19A1 | |
| SCHEMBL13242878 | 0.77 | SIGMAR1 (0.68) | SIGMAR1MAOAMAOBHTR1ACYP19A1 | |
| SCHEMBL10559365 | 0.77 | SIGMAR1 (0.68) | SIGMAR1MAOAMAOBHTR1ACYP19A1 | |
| SCHEMBL1801297 | 0.77 | SIGMAR1 (0.68) | SIGMAR1MAOAMAOBHTR1ACYP19A1 | |
| SCHEMBL14618789 | 0.75 | SIGMAR1 (0.61) | SIGMAR1MAOAMAOBHTR1AHTR1D | |
| SCHEMBL10556142 | 0.75 | SIGMAR1 (0.61) | SIGMAR1 | |
| SCHEMBL4572867 | 0.75 | SIGMAR1 (0.60) | SIGMAR1HTR1AHTR1DHTR1BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847269-A | GLAUCOMA, AMIDES OR UREA DERIVATIVES OF AMINOETHYLCARBOXY COMPOUNDS | SYNTEX (U.S.A.) INC. (US) | 1989-07-11 | — | — | US | disclosed |
| US-4629730-A | ADMINISTERING DIALKYL OR CYCLOAKYL AMINO ETHYLANILINE DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1986-12-16 | — | — | US | disclosed |
| EP-0180994-A2 | Antihypertensive dialkyl aminoethylaniline derivatives | SYNTEX (U.S.A.) INC. (US) | 1986-05-14 | — | — | EP | disclosed |