Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 1/20 | 0.41 |
| ▸ | DUT | P33316 | 8/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | P2RY6 | Q15077 | 4/20 | 0.33 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.33 |
| ▸ | NT5E | P21589 | 1/20 | 0.33 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.32 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1050827 | 0.90 | TYMP (0.41) | TYMPDUTP2RY14P2RY6P2RY2 | |
| SCHEMBL1052781 | 0.90 | TYMP (0.41) | TYMPDUTP2RY14P2RY6P2RY2 | |
| SCHEMBL1054738 | 0.86 | TYMP (0.42) | TYMPDUTP2RY14P2RY6P2RY2 | |
| SCHEMBL13010041 | 0.84 | TYMP (0.51) | TYMPP2RY14P2RY6P2RY2 | |
| SCHEMBL20503186 | 0.84 | TYMP (0.51) | TYMPP2RY14P2RY6P2RY2 | |
| SCHEMBL17223118 | 0.84 | TYMP (0.51) | TYMPP2RY14P2RY6P2RY2 | |
| SCHEMBL1582059 | 0.84 | TYMP (0.51) | TYMPP2RY14P2RY6P2RY2 | |
| SCHEMBL6363037 | 0.84 | TYMP (0.51) | TYMPP2RY14P2RY6P2RY2 | |
| SCHEMBL12960266 | 0.83 | TYMP (0.41) | TYMPDUTP2RY14P2RY6P2RY2 | |
| SCHEMBL1052839 | 0.83 | TYMP (0.38) | TYMPDUTP2RY14NT5ESLC6A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677822-B1 | 4'-THIONUCLEOSIDES AND OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS INC (US) | 2014-04-23 | — | — | EP | disclosed |
| US-7939677-B2 | Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation | ISIS PHARMACEUTICALS, INC. (US) | 2011-05-10 | — | — | US | disclosed |
| US-7875733-B2 | Nucleosides; RNA interference; gene expression inhibition; for use in therapeutic, diagnostic, and research applications involving gene silencing | ISIS PHARMACEUTICALS, INC. (US) | 2011-01-25 | — | — | US | disclosed |
| US-20100324277-A1 | OLIGOMERIC COMPOUNDS COMPRISING 4'-THIONUCLEOSIDES FOR USE IN GENE MODULATION | ISIS PHARMACEUTICALS, INC. (US) | 2010-12-23 | — | — | US | disclosed |
| US-20050130923-A1 | Nucleosides; RNA interference; gene expression inhibition; for use in therapeutic, diagnostic, and research applications involving gene silencing | IONIS PHARMACEUTICALS, INC. | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324277-A1 | OLIGOMERIC COMPOUNDS COMPRISING 4'-THIONUCLEOSIDES FOR USE IN GENE MODULATION | SNRPE, NSUN3, NSUN2 | TYMP 2257/4885DUT 280/4885P2RY14 4501/4885 |
| US-20050130923-A1 | Nucleosides; RNA interference; gene expression inhibition; for use in therapeutic, diagnostic, and research applications involving gene silencing | NSUN2, SNRPE, SNRPA | TYMP 687/4885DUT 98/4885P2RY14 4286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.