Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.44 |
| ▸ | PDE4A | P27815 | 6/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667675 | 0.84 | KCNH2 (0.52) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9669040 | 0.83 | SMN1; SMN2 (0.60) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9667476 | 0.82 | PDE3B (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9669024 | 0.82 | PDE3B (0.46) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9669200 | 0.82 | PDE3B (0.42) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9667792 | 0.81 | PDE3B (0.43) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9669258 | 0.81 | PDE3B (0.43) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9669379 | 0.81 | PDE3B (0.45) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10770050 | 0.81 | PDE3B (0.43) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11213151 | 0.79 | SMN1; SMN2 (0.59) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4851406-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-25 | — | — | US | disclosed |