Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 13/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.51 |
| ▸ | PDE4A | P27815 | 7/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6849455 | 0.84 | AXL (0.58) | SMN1; SMN2PDE3BPDE3ACYP3A4CYP2C9 | |
| SCHEMBL10558463 | 0.79 | PDE3B (0.44) | SMN1; SMN2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10353452 | 0.79 | SMN1; SMN2 (0.81) | SMN1; SMN2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10770050 | 0.78 | PDE3B (0.43) | SMN1; SMN2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10770060 | 0.78 | GPR119 (0.45) | SMN1; SMN2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL2592010 | 0.78 | GPR119 (0.72) | — | |
| SCHEMBL10518299 | 0.78 | GPR119 (0.59) | SMN1; SMN2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7263634 | 0.77 | KCNH2 (0.73) | SMN1; SMN2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9369671 | 0.76 | PDE3B (0.53) | SMN1; SMN2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10473667 | 0.74 | KCNH2 (0.50) | SMN1; SMN2PDE3BPDE3APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0029103-B1 | 6- AND 8-HETEROARYL-1,2,4-TRIAZOLO(4,3-B)PYRIDAZINES | AMERICAN CYANAMID COMPANY (US) | 1983-05-18 | — | — | EP | disclosed |
| US-4260756-A | TRANQUILIZERS | AMERICAN CYANAMID COMPANY (US) | 1981-04-07 | — | — | US | disclosed |