Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30609918 | 0.86 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL6073024 | 0.84 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL603957 | 0.78 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL16893309 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL5787375 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL1870162 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL6819973 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL2621378 | 0.75 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL2621382 | 0.75 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL70762 | 0.75 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863903-A | RENIN ENZYME INHIBITORS, HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |
| US-4719288-A | HYPOTENSIVE | CIBA-GEIGY CORPORATION (US) | 1988-01-12 | — | — | US | disclosed |
| US-4613676-A | PEPTIDES | CIBA-GEIGY CORPORATION (US) | 1986-09-23 | — | — | US | disclosed |
| EP-0143746-A2 | 5-Amino 4-hydroxy-valeryl-substituted derivatives | CIBA-GEIGY AG (CH) | 1985-06-05 | — | — | EP | disclosed |