Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 4/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10564675 | 0.90 | PDE4B (0.45) | ALDH1A1KDM4EHTTTSHRL3MBTL1 | |
| SCHEMBL10566832 | 0.89 | KDM4E (0.46) | ALDH1A1KDM4EKMT2AHSD17B10PDE4A | |
| SCHEMBL10565453 | 0.86 | KDM4E (0.48) | ALDH1A1KDM4EKMT2AHSD17B10PDE4A | |
| SCHEMBL10567284 | 0.84 | MAPT (0.48) | ALDH1A1KDM4EKMT2AHSD17B10HTT | |
| SCHEMBL10568294 | 0.84 | TSHR (0.50) | ALDH1A1KDM4EHTTTSHRL3MBTL1 | |
| SCHEMBL10567745 | 0.83 | CYP3A4 (0.53) | ALDH1A1PDE4APDE4DMAPTPDE4B | |
| SCHEMBL10566701 | 0.82 | HK1 (0.42) | ALDH1A1HSD17B10HTTTSHRL3MBTL1 | |
| SCHEMBL10567511 | 0.81 | KDM4E (0.50) | ALDH1A1KDM4EKMT2AHSD17B10HTT | |
| SCHEMBL9834662 | 0.78 | PDE4B (0.52) | ALDH1A1KDM4EKMT2AHSD17B10HTT | |
| SCHEMBL9834667 | 0.78 | PDE4B (0.52) | ALDH1A1KDM4EKMT2AHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824851-A | Pyrimidones as cardiotonic, anti hypertensive, cerebrovascular vasodilator and anti-platelet agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0123402-B1 | PYRIMIDINE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-09-07 | — | — | EP | disclosed |
| US-4746664-A | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-05-24 | — | — | US | disclosed |
| US-4612376-A | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-09-16 | — | — | US | disclosed |
| EP-0123402-A2 | Pyrimidine derivatives, preparation thereof and use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-10-31 | — | — | EP | disclosed |