Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 10/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10568957 | 0.88 | PDE4A (0.48) | CYP3A4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10565552 | 0.83 | ALDH1A1 (0.44) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL10564675 | 0.82 | PDE4B (0.45) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL10571200 | 0.80 | PDE4A (0.48) | CYP3A4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10571197 | 0.80 | PDE4A (0.48) | CYP3A4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10567284 | 0.79 | MAPT (0.48) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL10568294 | 0.79 | TSHR (0.50) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10566701 | 0.77 | HK1 (0.42) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL18931672 | 0.74 | RGS4 (0.52) | HPGDLMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL10566832 | 0.72 | KDM4E (0.46) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824851-A | Pyrimidones as cardiotonic, anti hypertensive, cerebrovascular vasodilator and anti-platelet agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0123402-B1 | PYRIMIDINE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-09-07 | — | — | EP | disclosed |
| US-4746664-A | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-05-24 | — | — | US | disclosed |
| US-4612376-A | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-09-16 | — | — | US | disclosed |
| EP-0123402-A2 | Pyrimidine derivatives, preparation thereof and use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-10-31 | — | — | EP | disclosed |