Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TNFSF11 | O14788 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10738160 | 0.90 | MEN1 (0.42) | KMT2AMEN1TDP1HTTL3MBTL1 | |
| Oxalic Acid SCHEMBL10566788 | 0.87 | KMT2A (0.44) | KMT2AMEN1TDP1HTTL3MBTL1 | |
| SCHEMBL10737106 | 0.86 | KMT2A (0.44) | KMT2AMEN1TDP1HTTL3MBTL1 | |
| SCHEMBL9811297 | 0.81 | KMT2A (0.47) | KMT2AMEN1TDP1HTTL3MBTL1 | |
| SCHEMBL9811381 | 0.81 | KMT2A (0.46) | KMT2AMEN1TDP1HTTL3MBTL1 | |
| SCHEMBL10572923 | 0.79 | KMT2A (0.45) | KMT2AMEN1TDP1HTTL3MBTL1 | |
| Oxalic Acid SCHEMBL10738176 | 0.77 | MEN1 (0.44) | KMT2AMEN1TDP1L3MBTL1KDM4E | |
| SCHEMBL9811367 | 0.77 | KDM4E (0.40) | KMT2AMEN1TDP1KDM4EMAPT | |
| SCHEMBL10734675 | 0.74 | SIGMAR1 (0.49) | KMT2AMEN1TDP1HTTKDM4E | |
| Oxalic Acid SCHEMBL9811373 | 0.74 | KDM4E (0.40) | KMT2AMEN1TDP1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847294-A | Derivatives of 2-(substituted sulfamyl)-6-nitrobenzoic acids, useful as adjuncts to radiation therapy | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0265806-A1 | 2-(Substituted sulfamyl)-6-nitrobenzoic acids, amides and esters thereof useful as adjuncts to radiation therapy | MERCK & CO. INC. (US) | 1988-05-04 | — | — | EP | disclosed |
| US-4694020-A | Derivatives of 2-(substituted sulfamyl)-6-nitrobenzoic acids and pharmaceutical compositions | MERCK & CO., INC. (US) | 1987-09-15 | — | — | US | disclosed |