Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.85 |
| ▸ | HTR3A | P46098 | 1/20 | 0.85 |
| ▸ | USP2 | O75604 | 1/20 | 0.85 |
| ▸ | LMNA | P02545 | 1/20 | 0.85 |
| ▸ | TSHR | P16473 | 1/20 | 0.85 |
| ▸ | HTT | P42858 | 1/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.85 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | HTR1D | P28221 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2167865 | 0.92 | HRH4 (1.00) | HRH4HTR3AUSP2LMNATSHR | |
| SCHEMBL2166566 | 0.90 | HRH4 (0.94) | HRH4HTR3AUSP2LMNATSHR | |
| SCHEMBL27927184 | 0.89 | USP2 (0.74) | HRH4HTR3AUSP2LMNATSHR | |
| SCHEMBL2166919 | 0.84 | HRH4 (0.85) | HRH4HTR3AUSP2LMNATSHR | |
| Hydrochloric Acid SCHEMBL603952 | 0.83 | HRH4 (0.82) | HRH4HTR3AUSP2LMNATSHR | |
| Hydrochloric Acid SCHEMBL6508476 | 0.83 | LMNA (0.65) | HRH4HTR3AUSP2LMNATSHR | |
| SCHEMBL602911 | 0.82 | HRH4 (0.65) | HRH4HTR3AUSP2LMNATSHR | |
| SCHEMBL2165190 | 0.81 | HRH4 (0.80) | HRH4HTR3AUSP2LMNATSHR | |
| Hydrochloric Acid SCHEMBL604845 | 0.81 | HRH4 (0.64) | HRH4HTR3AUSP2LMNATSHR | |
| SCHEMBL27927181 | 0.80 | HRH4 (0.61) | HRH4HTR3AUSP2LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4795812-A | ANTITUMOR | THE UPJOHN COMPANY (US) | 1989-01-03 | — | — | US | disclosed |
| EP-0210228-A1 | 4-SUBSTITUTED-6-ARYL PYRIMIDINE COMPOUNDS | THE UPJOHN COMPANY (US) | 1987-02-04 | — | — | EP | disclosed |
| WO-1986004583-A1 | 4-SUBSTITUTED-6-ARYL PYRIMIDINE COMPOUNDS | THE UPJOHN COMPANY (US) | 1986-08-14 | — | — | WO | disclosed |