Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.58 |
| ▸ | METAP1 | P53582 | 8/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | METAP2 | P50579 | 5/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA3 | P07451 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10568018 | 0.81 | AURKA (0.61) | AURKAAURKBMETAP1PDE4APDE4B | |
| SCHEMBL10566906 | 0.81 | AURKA (0.60) | AURKAAURKBMETAP1PDE4APDE4B | |
| SCHEMBL10507210 | 0.80 | PDE3B (0.40) | AURKAAURKBMETAP1PDE4APDE4B | |
| SCHEMBL10565692 | 0.79 | AURKA (0.58) | AURKAAURKBMETAP1PDE4APDE4B | |
| SCHEMBL10563422 | 0.79 | AURKA (0.61) | AURKAAURKBMETAP1PDE4APDE4B | |
| SCHEMBL10568144 | 0.79 | AURKA (0.58) | AURKAAURKBMETAP1PDE4APDE4B | |
| SCHEMBL10569142 | 0.79 | PDE3B (0.59) | AURKAAURKBMETAP1PDE4APDE4B | |
| SCHEMBL10568249 | 0.79 | AURKA (0.58) | AURKAAURKBMETAP1PDE4APDE4B | |
| SCHEMBL9382195 | 0.78 | METAP1 (0.54) | AURKAAURKBMETAP1PDE4APDE4B | |
| SCHEMBL10567386 | 0.78 | AURKA (0.91) | AURKAAURKBMETAP1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4835280-A | Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| US-4695567-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them and method of using them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1987-09-22 | — | — | US | disclosed |
| EP-0189103-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1986-07-30 | — | — | EP | disclosed |