Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.58 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.56 |
| ▸ | PDE4A | P27815 | 5/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.56 |
| ▸ | PGR | P06401 | 8/20 | 0.33 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10568769 | 0.82 | AURKA (0.57) | AURKAAURKBPDE3BPDE3APDE4A | |
| SCHEMBL9835173 | 0.79 | PDE3B (0.54) | AURKAAURKBPDE3BPDE3APDE4A | |
| SCHEMBL10568018 | 0.79 | AURKA (0.61) | AURKAAURKBPDE3BPDE3APDE4A | |
| SCHEMBL10567478 | 0.79 | AURKA (0.58) | AURKAAURKBPDE3BPDE3APDE4A | |
| SCHEMBL10567386 | 0.78 | AURKA (0.91) | AURKAAURKBPDE3BPDE3APDE4A | |
| SCHEMBL10566906 | 0.78 | AURKA (0.60) | AURKAAURKBPDE3BPDE3APDE4A | |
| SCHEMBL10373374 | 0.78 | PDE3B (0.68) | AURKAAURKBPDE3BPDE3APDE4A | |
| SCHEMBL10568694 | 0.77 | AURKA (0.62) | AURKAAURKBPDE3BPDE3APDE4A | |
| Adibendan SCHEMBL9832050 | 0.77 | PDE3B (0.90) | AURKAAURKBPDE3BPDE3APDE4A | |
| SCHEMBL10568249 | 0.76 | AURKA (0.58) | AURKAAURKBPDE3BPDE3APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4835280-A | Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| US-4695567-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them and method of using them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1987-09-22 | — | — | US | disclosed |
| EP-0189103-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1986-07-30 | — | — | EP | disclosed |