Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 13/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 13/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28145391 | 0.86 | ADORA2A (0.59) | XDHADORA2ANUDT1ADORA1ADORA2B | |
| SCHEMBL26708031 | 0.82 | KDM4E (0.61) | XDHADORA2AKDM4EALDH1A1LMNA | |
| SCHEMBL3236957 | 0.81 | KDM4E (0.59) | XDHADORA2AKDM4EALDH1A1LMNA | |
| SCHEMBL27612323 | 0.81 | CSNK1A1 (0.55) | XDHADORA2AKDM4EALDH1A1LMNA | |
| SCHEMBL10568221 | 0.81 | XDH (0.54) | XDHADORA2AKDM4EALDH1A1LMNA | |
| SCHEMBL24309361 | 0.79 | ADORA2A (0.57) | XDHADORA2AKDM4EALDH1A1LMNA | |
| SCHEMBL27716588 | 0.79 | CSNK1A1 (0.53) | XDHADORA2AKDM4EALDH1A1LMNA | |
| SCHEMBL10564429 | 0.78 | ADORA2A (0.50) | XDHADORA2AKDM4EALDH1A1LMNA | |
| SCHEMBL11145225 | 0.78 | XDH (0.51) | XDHADORA2AKDM4EALDH1A1LMNA | |
| SCHEMBL10567530 | 0.78 | ADORA2A (0.53) | XDHADORA2AKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4795812-A | ANTITUMOR | THE UPJOHN COMPANY (US) | 1989-01-03 | — | — | US | claimed |
| EP-0210228-A1 | 4-SUBSTITUTED-6-ARYL PYRIMIDINE COMPOUNDS | THE UPJOHN COMPANY (US) | 1987-02-04 | — | — | EP | claimed |
| WO-1986004583-A1 | 4-SUBSTITUTED-6-ARYL PYRIMIDINE COMPOUNDS | THE UPJOHN COMPANY (US) | 1986-08-14 | — | — | WO | claimed |
| US-4795812-A | ANTITUMOR | THE UPJOHN COMPANY (US) | 1989-01-03 | — | — | US | disclosed |
| EP-0210228-A1 | 4-SUBSTITUTED-6-ARYL PYRIMIDINE COMPOUNDS | THE UPJOHN COMPANY (US) | 1987-02-04 | — | — | EP | disclosed |
| WO-1986004583-A1 | 4-SUBSTITUTED-6-ARYL PYRIMIDINE COMPOUNDS | THE UPJOHN COMPANY (US) | 1986-08-14 | — | — | WO | disclosed |