Sugi Predict

Sugi Predict / Targets / XDH

XDH

Xanthine dehydrogenase/oxidase · P47989 · XDH on Sugi Atlas →

98,513 patent compounds predicted against XDH, 60,604 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL31601 SCHEMBL31601 0.80 9/20
SCHEMBL79000 SCHEMBL79000 0.51 9/20
SCHEMBL31574 SCHEMBL31574 0.50 9/20
SCHEMBL48425 SCHEMBL48425 0.50 9/20
SCHEMBL41787 SCHEMBL41787 0.59 8/20
SCHEMBL20578 SCHEMBL20578 0.58 8/20
9-Methylguanine 9-Methylguanine (SCHEMBL22884) 0.58 8/20
Bropirimine Bropirimine (SCHEMBL4058) 0.57 8/20
SCHEMBL72147 SCHEMBL72147 0.50 8/20
Quercetin Quercetin (SCHEMBL19723) 1.00 7/20
Oxypurinol Oxypurinol (SCHEMBL39154) 1.00 7/20
Quercetin Quercetin (SCHEMBL118425) 1.00 7/20
SCHEMBL31573 SCHEMBL31573 0.69 7/20
SCHEMBL117527 SCHEMBL117527 0.67 7/20
SCHEMBL31602 SCHEMBL31602 0.52 7/20
SCHEMBL48090 SCHEMBL48090 0.51 7/20
Kaempferol Kaempferol (SCHEMBL18817) 1.00 6/20
Myricetin Myricetin (SCHEMBL19302) 1.00 6/20
Morin Morin (SCHEMBL19984) 1.00 6/20
Galangin Galangin (SCHEMBL117225) 1.00 6/20

Clinical trials — most relevant to XDH by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Treatment of Hyperuricemia in Patients With Heart Failure PHASE4COMPLETED
Allopurinol in Chronic Heart Failure PHASE4COMPLETED
Allopurinol and Trimetazidine as a Preventive of Acute Kidney Injury in PCI Patients PHASE4UNKNOWN
Effect of Allopurinol for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome PHASE3UNKNOWN
Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis PHASE2/PHASE3UNKNOWN
Combination Treatment Study in Subjects With Tophaceous Gout With Lesinurad and Febuxostat PHASE3COMPLETED
Allopurinol to Prevent Cirrhosis Related Morbidities PHASE2/PHASE3COMPLETED
Febuxostat Versus Allopurinol Control Trial in Subjects With Gout PHASE3COMPLETED
Impact of Diabetes on Left Ventricular Remodeling PHASE2/PHASE3COMPLETED
Effects of Febuxostat for Lowering Uric Acid in NAFLD Patients With Gout PHASE2UNKNOWN
Endothelial Dysfunction and Oxidative Stress in Children With Sleep Disordered Breathing. PHASE1/PHASE2COMPLETED
The Effect of Colchicine on the Pharmacokinetic Profile of LC350189 in Healthy Aldults. PHASE1COMPLETED
The Effect of Antioxidants on Skin Blood Flow During Local Heating PHASE1COMPLETED
Clinical Study to Evaluate the Possible Efficacy and Safety of Febuxostat in Patients With Ulcerative Colitis Treated With Mesalamine EARLY_PHASE1NOT_YET_RECRUITING
Uric Acid Metabolism, Endothelial Function and Oxidative Stress in Vegans and Omnivores. nanCOMPLETED
Purine Metabolism Enzyme SNP to Uric Acid Production nanCOMPLETED
Correlation of Genetic Polymorphism of Azathioprine Metabolizing Enzymes and Correlation to Clinical Adverse Effects nanCOMPLETED
XOR Levels in OSA Patients (XOR-OSA) nanRECRUITING
Mucomyst for Hepatitis C nanSUSPENDED
Effects of Anesthesia Technique on Endothelial Function nanCOMPLETED
Uric Acid Effects on Endothelium and Oxydative Stress nanCOMPLETED
Screening for Hyperuricemia in Patients With Metabolic Associated Fatty Liver Disease (MAFLD) nanNOT_YET_RECRUITING
Effect of Allopurinol on Left Ventricular Function in Children With Dilated Cardiomyopathy nanUNKNOWN
Registry of X-linked Adrenoleukodystrophy nanRECRUITING
Flow Mediated Dilation in Association With Hyperuricemia nanUNKNOWN
Reactive Oxygen Species Following Aortic Valve Replacement nanCOMPLETED
Gummy Candies With Maqui Berry nanCOMPLETED
Xanthine Oxidase and Uric Acid Origin in Preeclamptic Women nanUNKNOWN
Relationship Between Serum Xanthine Oxidase Levels and Seborrheic Keratosis nanCOMPLETED
Study of the Effects of the Consumption of Different Products Cocoa Derivatives at the Risk of Crystallization of Uric Acid in Urine of Volunteers. nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a XDH binder may also engage these)

ProteinNameSimilarity
Q00519 — 1.000 Q00519 →
Q9MYW6 — 1.000 Q9MYW6 →
P80457 — 1.000 P80457 →
P22985 — 1.000 P22985 →
P47990 — 1.000 P47990 →
P10351 — 1.000 P10351 →
O54754 — 1.000 O54754 →
Q12553 — 1.000 Q12553 →
P48034 — 1.000 P48034 →
Q5QE79 — 1.000 Q5QE79 →
P80456 — 1.000 P80456 →
AOX1 Aldehyde oxidase 0.999 landscape →
P08793 — 0.998 P08793 →
C4NYZ3 — 0.997 C4NYZ3 →
H9TB17 — 0.997 H9TB17 →
Q5FB27 — 0.996 Q5FB27 →
R4ZGN4 — 0.996 R4ZGN4 →
Q6AUV1 — 0.996 Q6AUV1 →
Q9Z0U5 — 0.996 Q9Z0U5 →
Q5SGK3 — 0.996 Q5SGK3 →
Q8GUQ8 — 0.995 Q8GUQ8 →
H9TB18 — 0.994 H9TB18 →
Q5QE78 — 0.994 Q5QE78 →
F4JLI5 — 0.993 F4JLI5 →
Q7G192 — 0.993 Q7G192 →
P22811 — 0.992 P22811 →
A0A1U8QNG8 — 0.992 A0A1U8QNG8 →
Q54FB7 — 0.992 Q54FB7 →
Q3TYQ9 — 0.992 Q3TYQ9 →
Q7G191 — 0.991 Q7G191 →