Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 12/20 | 0.56 |
| ▸ | HTR2B | P41595 | 12/20 | 0.56 |
| ▸ | HTR2A | P28223 | 11/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10350486 | 0.98 | HTR2C (0.54) | HTR2CHTR2BHTR2ASMN1; SMN2PNMT | |
| SCHEMBL10567704 | 0.85 | HTR2C (0.42) | HTR2CHTR2BHTR2ASMN1; SMN2PNMT | |
| SCHEMBL10962779 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2CA7TSHR | |
| Hydrochloric Acid SCHEMBL10351671 | 0.84 | HTR2A (0.57) | HTR2CHTR2BHTR2APNMTCA7 | |
| SCHEMBL10564873 | 0.81 | HTR2C (0.40) | HTR2CHTR2BHTR2APNMT | |
| Hydrochloric Acid SCHEMBL10350479 | 0.81 | HTR2C (0.52) | HTR2CHTR2BHTR2AKMT2ATSHR | |
| Hydrochloric Acid SCHEMBL10351660 | 0.81 | HTR2C (0.50) | HTR2CHTR2BHTR2APNMTCA7 | |
| Hydrochloric Acid SCHEMBL10350986 | 0.80 | HTR2C (0.49) | HTR2CHTR2BHTR2ACA7 | |
| Bromide SCHEMBL10351349 | 0.80 | HTR2C (0.39) | HTR2CHTR2BHTR2APNMT | |
| SCHEMBL3162737 | 0.80 | HTR2A (0.74) | HTR2CHTR2BHTR2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1988007858-A1 | SULFINYL AND SULFONYL SUBSTITUTED 3-BENZAZEPINES | SMITHKLINE BECKMAN CORPORATION (US) | 1988-10-20 | — | — | WO | claimed |
| US-4824839-A | Sulfinyl and sulfonyl substituted 2,3,4,5 tetrahydro-1H-3-benzazepines and their use in treating gastrointestinal motility disorders | SMITHKLINE BECKMAN CORPORATION (US) | 1989-04-25 | — | — | US | disclosed |
| WO-1988007858-A1 | SULFINYL AND SULFONYL SUBSTITUTED 3-BENZAZEPINES | SMITHKLINE BECKMAN CORPORATION (US) | 1988-10-20 | — | — | WO | disclosed |
| WO-1988007858-A1 | SULFINYL AND SULFONYL SUBSTITUTED 3-BENZAZEPINES | SMITHKLINE BECKMAN CORPORATION (US) | 1988-10-20 | — | — | WO | disclosed |
| EP-0229510-A1 | Sulfinyl and sulfonyl substituted-3-benzazepines | SMITHKLINE BEECHAM CORPORATION (US) | 1987-07-22 | — | — | EP | disclosed |