Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10568859 | 0.80 | PGR (0.38) | PGRTP53LMNAMAPTAKT1 | |
| SCHEMBL10565793 | 0.75 | PGR (0.38) | PGRTP53LMNAMAPTAKT1 | |
| SCHEMBL10566751 | 0.75 | PGR (0.36) | PGR | |
| SCHEMBL9834779 | 0.75 | PGR (0.47) | PGRTP53LMNAMAPT | |
| SCHEMBL10567263 | 0.74 | PGR (0.38) | PGRTP53LMNAMAPT | |
| SCHEMBL9834604 | 0.74 | PGR (0.46) | PGRTP53LMNAMAPT | |
| SCHEMBL9833666 | 0.74 | PGR (0.46) | PGRTP53LMNAMAPT | |
| SCHEMBL9835247 | 0.74 | PGR (0.46) | PGRTP53LMNAMAPT | |
| SCHEMBL9834376 | 0.74 | PGR (0.47) | PGRTP53LMNAMAPT | |
| SCHEMBL10569328 | 0.73 | PGR (0.41) | PGRTP53LMNAMAPTAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4835280-A | Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| US-4695567-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them and method of using them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1987-09-22 | — | — | US | disclosed |