Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | STK4 | Q13043 | 3/20 | 0.44 |
| ▸ | STK3 | Q13188 | 3/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19241997 | 0.86 | PIK3CA (0.52) | KDM4EGAAPDE10AMEN1KMT2A | |
| SCHEMBL10565483 | 0.85 | LMNA (0.45) | KDM4EMEN1KMT2AMAPK1PIK3CA | |
| SCHEMBL10569576 | 0.85 | KDM1A (0.48) | KDM4EGAAPDE10AMEN1KMT2A | |
| SCHEMBL10567632 | 0.84 | LMNA (0.48) | KDM4EMEN1KMT2ASTK3MAPK1 | |
| Hydrochloric Acid SCHEMBL10567129 | 0.83 | GAA (0.46) | KDM4EGAAPDE10AMEN1KMT2A | |
| SCHEMBL19241974 | 0.78 | KDM4E (0.54) | KDM4EGAAPDE10AMEN1KMT2A | |
| SCHEMBL17623135 | 0.76 | KDM4E (0.70) | KDM4EGAAPDE10AMEN1KMT2A | |
| SCHEMBL13828670 | 0.74 | SMN1; SMN2 (0.46) | KDM4EMEN1KMT2APIK3CAALDH1A1 | |
| SCHEMBL10884321 | 0.74 | PIK3CA (0.43) | KDM4EGAAPDE10AMEN1KMT2A | |
| SCHEMBL18431035 | 0.73 | KDM4E (0.42) | KDM4EGAAPDE10AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4820708-A | ANTISECRETORY AGENTS; GASTROINTESTINAL DISORDERS | SMITH KLINE & FRENCH LABORATORIES (GB) | 1989-04-11 | — | — | US | disclosed |
| US-4777172-A | ANTIGASTRIC ACID SECRETORY AGENT | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-10-11 | — | — | US | disclosed |
| CN-86102398-A | The preparation method of substituted benzimidazole derivative | — | 1986-11-12 | — | — | CN | disclosed |
| EP-0198583-A1 | Heterocyclic compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-10-22 | — | — | EP | disclosed |