Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5956975 | 0.89 | LMNA (0.49) | LMNAPOLBALDH1A1NPC1RAB9A | |
| SCHEMBL20101562 | 0.82 | LMNA (0.44) | LMNAPOLBALDH1A1NPC1RAB9A | |
| SCHEMBL23450919 | 0.81 | LMNA (0.50) | LMNAPOLBALDH1A1NPC1RAB9A | |
| SCHEMBL10569690 | 0.81 | LMNA (0.46) | LMNAPOLBALDH1A1NPC1RAB9A | |
| SCHEMBL23817360 | 0.79 | LMNA (0.44) | LMNAPOLBALDH1A1NPC1RAB9A | |
| SCHEMBL24245269 | 0.79 | LMNA (0.44) | LMNAPOLBALDH1A1NPC1RAB9A | |
| SCHEMBL26263091 | 0.78 | LMNA (0.41) | LMNAPOLBALDH1A1NPC1RAB9A | |
| SCHEMBL23602333 | 0.78 | LMNA (0.50) | LMNAPOLBALDH1A1NPC1RAB9A | |
| SCHEMBL17525783 | 0.78 | LMNA (0.50) | LMNAPOLBALDH1A1NPC1RAB9A | |
| SCHEMBL6278883 | 0.78 | LMNA (0.46) | LMNAPOLBALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4851399-A | Isoquinoline derivatives and their use as anti-cancer agents | GLAXO GROUP LIMITED (GB) | 1989-07-25 | — | — | US | disclosed |