SCHEMBL10569737

SCHEMBL10569737

N#CC(Cc1ccc(Br)cc1)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 4/20 0.56
ESR1 P03372 3/20 0.56
ALDH1A1 P00352 2/20 0.56
MEN1 O00255 1/20 0.56
CYP1A2 P05177 1/20 0.56
CYP3A4 P08684 1/20 0.56
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
KMT2A Q03164 1/20 0.56
HTR2A P28223 1/20 0.43
TRPA1 O75762 1/20 0.42
EPHX1 P07099 1/20 0.39
SIGMAR1 Q99720 1/20 0.39
TSHR P16473 1/20 0.38
CNR1 P21554 1/20 0.38
CNR2 P34972 1/20 0.38
LMNA P02545 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
NAAA Q02083 1/20 0.37
MME P08473 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1981578 0.93 ESR2 (0.56) ESR2ESR1ALDH1A1MEN1CYP1A2
SCHEMBL56063 0.87 ESR2 (0.60) ESR2ESR1ALDH1A1MEN1CYP1A2
SCHEMBL9127626 0.86 ESR2 (0.56) ESR2ESR1ALDH1A1MEN1CYP1A2
SCHEMBL11782475 0.83 HTR2A (0.41) ESR2ESR1ALDH1A1MEN1CYP1A2
SCHEMBL10564004 0.82 ESR2 (0.56) ESR2ESR1ALDH1A1MEN1CYP1A2
SCHEMBL11018798 0.82 ESR2 (0.56) ESR2ESR1ALDH1A1MEN1CYP1A2
SCHEMBL28978055 0.82 ESR2 (0.56) ESR2ESR1ALDH1A1MEN1CYP1A2
SCHEMBL5163915 0.82 ESR2 (0.56) ESR2ESR1ALDH1A1MEN1CYP1A2
SCHEMBL6383255 0.82 ESR2 (0.83) ESR2ESR1ALDH1A1MEN1CYP1A2
SCHEMBL11788128 0.82 ESR2 (0.56) ESR2ESR1ALDH1A1MEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113713858-B Alpha alkylation reaction catalyst of nitrile and preparation method thereof 郑州大学 2023-06-23 CN disclosed
CN-113559939-B Alpha alkylation reaction catalyst of nitrile and preparation method thereof 郑州大学 2023-06-23 CN disclosed
CN-113713858-A Alpha alkylation reaction catalyst of nitrile and preparation method thereof 郑州大学 2021-11-30 CN disclosed
CN-113559939-A Alpha alkylation reaction catalyst for nitrile and preparation method thereof 郑州大学 2021-10-29 CN disclosed
CN-110026244-B Alpha alkylation reaction catalyst of nitrile and application thereof 郑州大学 2021-06-18 CN disclosed
US-4874763-A ANTIARRHYTHMIA AGENTS ROEHM GMBH CHEMISCHE FABRIK (DE) 1989-10-17 US disclosed
EP-0318795-A2 Pharmaceutically active pteridin derivatives Röhm GmbH (DE) 1989-06-07 EP disclosed