Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.50 |
| ▸ | CYP2J2 | P51589 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9786858 | 0.80 | CYP2J2 (0.58) | HRH1KCNH2CYP2J2MEN1NPC1 | |
| SCHEMBL9556022 | 0.80 | CARM1 (0.48) | MEN1GAAHTR2AKMT2A | |
| SCHEMBL9874355 | 0.79 | CYP2J2 (0.61) | HRH1KCNH2CYP2J2LMNACYP3A4 | |
| SCHEMBL9872538 | 0.78 | CYP2J2 (0.58) | HRH1KCNH2CYP2J2LMNACYP3A4 | |
| SCHEMBL17023764 | 0.78 | HRH1 (0.77) | HRH1KCNH2CYP2J2 | |
| SCHEMBL9873292 | 0.78 | CYP2J2 (0.52) | HRH1KCNH2CYP2J2LMNACYP3A4 | |
| SCHEMBL9873332 | 0.78 | CYP2J2 (0.57) | HRH1KCNH2CYP2J2LMNACYP3A4 | |
| SCHEMBL9786852 | 0.76 | CYP19A1 (0.50) | HRH1KCNH2CYP2J2 | |
| SCHEMBL7442047 | 0.75 | KCNH2 (0.69) | HRH1KCNH2 | |
| SCHEMBL18609333 | 0.75 | HRH1 (0.78) | HRH1KCNH2CYP2J2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853387-A | Piperidine derivatives, and their application in therapy | SYNTHELABO (FR) | 1989-08-01 | — | — | US | disclosed |