Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GLS | O94925 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10573036 | 0.98 | CYP19A1 (0.58) | CYP19A1HPGDRECQLRAB9AKDM4E | |
| SCHEMBL10576900 | 0.98 | CYP19A1 (0.58) | CYP19A1HPGDRECQLRAB9AKDM4E | |
| SCHEMBL10572702 | 0.98 | CYP19A1 (0.58) | CYP19A1HPGDRECQLRAB9AKDM4E | |
| SCHEMBL10575267 | 0.97 | CYP19A1 (0.54) | CYP19A1HPGDRECQLRAB9AKDM4E | |
| SCHEMBL10578350 | 0.88 | CYP19A1 (0.45) | CYP19A1RAB9AGLSNPC1SIGMAR1 | |
| SCHEMBL10576105 | 0.82 | CYP19A1 (0.62) | CYP19A1HPGDRECQLRAB9AALDH1A1 | |
| SCHEMBL9506559 | 0.79 | HPGD (0.51) | HPGDRECQLRAB9AMEN1KMT2A | |
| SCHEMBL904457 | 0.79 | ALDH1A1 (0.45) | CYP19A1KDM4EALDH1A1KMT2AGLS | |
| SCHEMBL10571510 | 0.78 | HPGD (0.53) | HPGDRECQLRAB9AKDM4EALDH1A1 | |
| SCHEMBL10578516 | 0.77 | CYP19A1 (0.55) | CYP19A1HPGDRAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4877795-A | 4H-quinolizin-4-one compounds useful for the treatment of allergic bronchial asthma, allergic rhinitis atropic dermatitis and the like | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-10-31 | — | — | US | disclosed |
| EP-0277755-A1 | 4H-quinolizin-4-one compounds exhibiting therapeutic activities | Kissei Pharmaceutical Co. Ltd. (JP) | 1988-08-10 | — | — | EP | disclosed |