Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17229376 | 0.84 | AKR1B1 (0.44) | AKR1B1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL15767323 | 0.84 | AKR1B1 (0.44) | AKR1B1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL17221376 | 0.84 | AKR1B1 (0.44) | AKR1B1KDM4EALDH1A1POLBTDP1 | |
| Hydrochloric Acid SCHEMBL22613762 | 0.83 | AKR1B1 (0.44) | AKR1B1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL974491 | 0.81 | METTL3 (0.44) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL8172945 | 0.81 | KDM4E (0.63) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL15767586 | 0.80 | AKR1B1 (0.42) | AKR1B1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL5074964 | 0.79 | AKR1B1 (0.49) | AKR1B1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL754044 | 0.77 | AKR1B1 (0.38) | AKR1B1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL1905278 | 0.77 | KDM4E (0.38) | KDM4EALDH1A1POLBTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2740730-B1 | DIBENZOOXEPIN DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2016-11-16 | — | — | EP | disclosed |
| US-8969345-B2 | Dibenzooxepin derivative | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2015-03-03 | — | — | US | disclosed |
| US-20140163008-A1 | DIBENZOOXEPIN DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2014-06-12 | — | — | US | disclosed |
| EP-2740730-A1 | DIBENZOOXEPIN DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2014-06-11 | — | — | EP | disclosed |
| US-20130131021-A1 | ANALOGUES OF CILOSTAZOL | CONCERT PHARMACEUTICALS INC. (US) | 2013-05-23 | — | — | US | disclosed |
| EP-0322153-A2 | Heterocyclic oxophtalazinyl acetic acids | PFIZER INC. (US) | 1989-06-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131021-A1 | ANALOGUES OF CILOSTAZOL | PDE3A, PDE3B, PDE5A | AKR1B1 813/4885KDM4E 1163/4885ALDH1A1 1189/4885 |
| US-20140163008-A1 | DIBENZOOXEPIN DERIVATIVE | PPARA, PPARG, PPARD | AKR1B1 616/4885KDM4E 1605/4885ALDH1A1 1394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.