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Sugi Predict / Targets / METTL3

METTL3

N6-adenosine-methyltransferase catalytic subunit · Q86U44 · METTL3 on Sugi Atlas →

25,029 patent compounds predicted against METTL3, 13,294 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL305699 SCHEMBL305699 0.55 18/20
SCHEMBL459667 SCHEMBL459667 0.52 15/20
SCHEMBL1134947 SCHEMBL1134947 0.56 12/20
SCHEMBL823315 SCHEMBL823315 0.54 12/20
SCHEMBL1134858 SCHEMBL1134858 0.55 10/20
SCHEMBL870154 SCHEMBL870154 0.58 8/20
SCHEMBL869590 SCHEMBL869590 0.46 7/20
SCHEMBL870522 SCHEMBL870522 0.43 7/20
SCHEMBL870030 SCHEMBL870030 0.52 5/20
SCHEMBL543898 SCHEMBL543898 0.50 5/20
SCHEMBL474780 SCHEMBL474780 0.47 5/20
SCHEMBL873112 SCHEMBL873112 0.47 5/20
SCHEMBL868173 SCHEMBL868173 0.41 5/20
SCHEMBL439632 SCHEMBL439632 0.40 5/20
SCHEMBL1134904 SCHEMBL1134904 0.52 4/20
SCHEMBL458447 SCHEMBL458447 0.39 4/20
SCHEMBL889285 SCHEMBL889285 0.53 3/20
SCHEMBL458344 SCHEMBL458344 0.53 3/20
SCHEMBL846337 SCHEMBL846337 0.51 3/20
SCHEMBL890511 SCHEMBL890511 0.48 3/20

Clinical trials — most relevant to METTL3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN) nanUNKNOWN
Prognosis of METTL-14 in Endometrial Carcinoma nanNOT_YET_RECRUITING
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study nanNOT_YET_RECRUITING
Using the Epitranscriptome to Diagnose and Treat Gliomas nanRECRUITING
Molecular Profiling for Risk Stratification in Appendiceal Cancer nanRECRUITING
Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac Surgery nanRECRUITING
The Molecular Pathogenesis Study of Cataract nanUNKNOWN
Impact of Weight Loss on the Human Sperm Epitranscriptome nanACTIVE_NOT_RECRUITING
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population nanCOMPLETED
Search for Bovine miRNA Transference to Humans nanCOMPLETED
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients nanRECRUITING
miR-155 Expression in Episodic and Chronic Migraine nanUNKNOWN
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy nanUNKNOWN
Apelin12 in Acne Vulgaris nanUNKNOWN
Methylation of DNA in Children and Adolescents With Type 1 Diabetes Mellitus (METHYLDIAB) nanCOMPLETED
The Effect of Exercise Training on lncRNA Expression in Rheumatoid Arthritis nanRECRUITING
Exosomal microRNAs as a Biomarker in Panic Disorder and in Response to CBT nanUNKNOWN
RNA Sequencing in the Framingham Heart Study Third Generation Cohort Exam 2 nanCOMPLETED
Plasma 5hmC Signatures as a Marker of Colorectal / Appendiceal Peritoneal Metastasis nanACTIVE_NOT_RECRUITING
SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases nanNOT_YET_RECRUITING
Impact Of Choline in Patients With NAFLD nanUNKNOWN
Transcripts with Retained H/ACA Box SnoRNA Sequences As Biomarkers for Estrogen Dependence in Lum-B Breast Carcinomas nanACTIVE_NOT_RECRUITING
Effects of Contact Restrictions During the COVID-19 Pandemic on Newborns and Their Parents nanCOMPLETED
Assessment Of Long Noncoding RNA CCAT1 In Colorectal Cancer Patients nanUNKNOWN
Genomics and Epigenomics for New Insights in fEmale OAB (GENIE) Study nanCOMPLETED
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis nanCOMPLETED
The Value of circRNAs (hsa_circ_0004001) in Early Diagnosis of HCC nanUNKNOWN
Emotional Regulation in Children With ND: the Role of Genomic Variation, Proteomic Patterns, and Early Experience nanUNKNOWN
Research on the Early and Prognosis Diagnosis of Vascular Dementia nanRECRUITING
Use of Omics Methods to Classify Variations of Uncertain Significance and Improve Diagnosis of Neurogenetic Diseases nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a METTL3 binder may also engage these)

ProteinNameSimilarity
Q8C3P7 — 1.000 Q8C3P7 →
F1R777 — 0.997 F1R777 →
Q9VCE6 — 0.983 Q9VCE6 →
A1D4V5 — 0.981 A1D4V5 →
Q338B9 — 0.980 Q338B9 →
Q6EU10 — 0.979 Q6EU10 →
Q69ZX6 — 0.978 Q69ZX6 →
A1CS00 — 0.977 A1CS00 →
Q0CWI2 — 0.977 Q0CWI2 →
Q2HVD6 — 0.976 Q2HVD6 →
P38093 — 0.976 P38093 →
Q8N1G2 — 0.976 Q8N1G2 →
Q7S1P9 — 0.976 Q7S1P9 →
Q2UM19 — 0.976 Q2UM19 →
O82486 — 0.976 O82486 →
Q8CI95 — 0.975 Q8CI95 →
Q00578 — 0.975 Q00578 →
E9Q4Z2 — 0.975 E9Q4Z2 →
Q60HG1 — 0.975 Q60HG1 →
Q8CG07 — 0.975 Q8CG07 →
Q8K339 — 0.975 Q8K339 →
Q1RMT1 — 0.975 Q1RMT1 →
Q4G005 — 0.975 Q4G005 →
Q8CCP0 — 0.975 Q8CCP0 →
Q803R5 — 0.975 Q803R5 →
B5DDX6 — 0.975 B5DDX6 →
Q9BXB4 — 0.975 Q9BXB4 →
Q5R981 — 0.974 Q5R981 →
Q5ZKK7 — 0.974 Q5ZKK7 →
Q4WN42 — 0.974 Q4WN42 →