SCHEMBL10588182

SCHEMBL10588182

Cc1cc2cc3c(C)c(CCl)c(=O)oc3c(C)c2o1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.54
KDM4E B2RXH2 4/20 0.54
MAPK1 P28482 2/20 0.54
CYP1A2 P05177 1/20 0.54
CYP3A4 P08684 1/20 0.54
MAOA P21397 1/20 0.54
HTR2C P28335 1/20 0.54
ADORA2A P29274 1/20 0.54
GPR35 Q9HC97 1/20 0.39
POLB P06746 4/20 0.38
TP53 P04637 1/20 0.38
MAPT P10636 1/20 0.38
HSD17B10 Q99714 4/20 0.37
GLA P06280 3/20 0.37
GAA P10253 3/20 0.37
HPGD P15428 3/20 0.37
CASP1 P29466 3/20 0.37
CASP7 P55210 3/20 0.37
ERAP1 Q9NZ08 2/20 0.37
HTT P42858 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7989481 0.85 KDM4E (0.54) ALDH1A1KDM4EMAPK1CYP1A2CYP3A4
SCHEMBL756454 0.85 ALDH1A1 (0.54) ALDH1A1KDM4EMAPK1CYP1A2CYP3A4
Hydrochloric Acid SCHEMBL6991180 0.84 ALDH1A1 (0.52) ALDH1A1KDM4EMAPK1CYP1A2CYP3A4
SCHEMBL11408643 0.84 ALDH1A1 (0.52) ALDH1A1KDM4EMAPK1CYP1A2CYP3A4
SCHEMBL7632180 0.83 ALDH1A1 (0.51) ALDH1A1KDM4EMAPK1CYP1A2CYP3A4
SCHEMBL5011938 0.82 ALDH1A1 (0.65) ALDH1A1KDM4EMAPK1CYP1A2CYP3A4
SCHEMBL8504877 0.80 KDM4E (0.46) ALDH1A1KDM4EMAPK1CYP1A2CYP3A4
SCHEMBL6991692 0.78 MAPK1 (0.46) ALDH1A1KDM4EMAPK1CYP1A2CYP3A4
SCHEMBL16872346 0.77 MAPK1 (0.58) ALDH1A1KDM4EMAPK1CYP1A2CYP3A4
SCHEMBL499204 0.77 ALDH1A1 (0.58) ALDH1A1KDM4EMAPK1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0319957-A2 A method for modifying the surface of a polymer GLUETECH APS (DK) 1989-06-14 EP disclosed