Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.30 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.30 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10596773 | 0.91 | SMN1; SMN2 (0.33) | GAASMN1; SMN2L3MBTL1POLBTP53 | |
| SCHEMBL10595798 | 0.88 | MEN1 (0.33) | SMN1; SMN2POLBHDAC1HDAC2MAPT | |
| SCHEMBL10594005 | 0.88 | POLB (0.37) | SMN1; SMN2POLBHDAC1HDAC2MAPT | |
| SCHEMBL10597320 | 0.88 | POLB (0.37) | SMN1; SMN2POLBHDAC1HDAC2MAPT | |
| SCHEMBL10595214 | 0.84 | GAA (0.34) | GAASMN1; SMN2L3MBTL1POLBTP53 | |
| SCHEMBL10401867 | 0.83 | TSHR (0.34) | GAASMN1; SMN2POLBHDAC1HDAC2 | |
| SCHEMBL10401792 | 0.80 | POLB (0.37) | SMN1; SMN2POLB | |
| SCHEMBL10802418 | 0.79 | SMN1; SMN2 (0.33) | SMN1; SMN2POLB | |
| SCHEMBL10596819 | 0.79 | SMN1; SMN2 (0.33) | SMN1; SMN2POLB | |
| SCHEMBL11423317 | 0.77 | MAPT (0.39) | GAASMN1; SMN2POLBMAPTPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0131174-B1 | SUBSTITUTED PHENYLGLYCINE DERIVATIVES OF BETA-LACTAM ANTIBIOTICS | BEECHAM GROUP PLC (GB) | 1989-09-13 | — | — | EP | disclosed |
| US-4684639-A | Antibacterial penicillins and cephalosporins | BEECHAM GROUP (GB) | 1987-08-04 | — | — | US | disclosed |
| EP-0131174-A1 | Substituted phenylglycine derivatives of beta-lactam antibiotics | BEECHAM GROUP PLC (GB) | 1985-01-16 | — | — | EP | disclosed |