Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10594166 | 0.91 | GAA (0.32) | SMN1; SMN2POLBTP53GAAL3MBTL1 | |
| SCHEMBL10401792 | 0.89 | POLB (0.37) | SMN1; SMN2POLB | |
| SCHEMBL10802418 | 0.88 | SMN1; SMN2 (0.33) | SMN1; SMN2POLB | |
| SCHEMBL9770262 | 0.83 | POLB (0.35) | SMN1; SMN2POLBGAAALDH1A1 | |
| SCHEMBL10594005 | 0.81 | POLB (0.37) | SMN1; SMN2POLB | |
| SCHEMBL10597320 | 0.81 | POLB (0.37) | SMN1; SMN2POLB | |
| SCHEMBL11093687 | 0.80 | MC4R (0.37) | SMN1; SMN2POLBTP53 | |
| SCHEMBL10595798 | 0.79 | MEN1 (0.33) | SMN1; SMN2POLB | |
| SCHEMBL10596819 | 0.78 | SMN1; SMN2 (0.33) | SMN1; SMN2POLB | |
| SCHEMBL10490784 | 0.78 | MAPT (0.37) | SMN1; SMN2POLBGAAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0131174-B1 | SUBSTITUTED PHENYLGLYCINE DERIVATIVES OF BETA-LACTAM ANTIBIOTICS | BEECHAM GROUP PLC (GB) | 1989-09-13 | — | — | EP | disclosed |
| US-4684639-A | Antibacterial penicillins and cephalosporins | BEECHAM GROUP (GB) | 1987-08-04 | — | — | US | disclosed |
| EP-0131174-A1 | Substituted phenylglycine derivatives of beta-lactam antibiotics | BEECHAM GROUP PLC (GB) | 1985-01-16 | — | — | EP | disclosed |