Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 9/20 | 0.46 |
| ▸ | PPARD | Q03181 | 8/20 | 0.46 |
| ▸ | PPARA | Q07869 | 8/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TLR2 | O60603 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | FABP4 | P15090 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10595117 | 1.00 | ALOX5 (0.54) | ALOX5PPARGPPARDPPARAGPR84 | |
| SCHEMBL10595426 | 0.91 | ALOX5 (0.52) | ALOX5PPARGPPARDPPARAGPR84 | |
| SCHEMBL10595431 | 0.91 | ALOX5 (0.52) | ALOX5PPARGPPARDPPARAGPR84 | |
| SCHEMBL11513898 | 0.89 | ALOX5 (0.67) | ALOX5PPARGPPARDPPARAGPR84 | |
| SCHEMBL10980014 | 0.84 | TOP1 (0.48) | ALOX5PPARGPPARDPPARAPTPN1 | |
| SCHEMBL10596324 | 0.84 | TOP1 (0.48) | ALOX5PPARGPPARDPPARAPTPN1 | |
| SCHEMBL10594110 | 0.84 | TOP1 (0.48) | PPARGPPARDPPARAPTPN1TDP1 | |
| SCHEMBL10594014 | 0.84 | TOP1 (0.48) | PPARGPPARDPPARAPTPN1TDP1 | |
| SCHEMBL10594944 | 0.84 | KDM5A (0.44) | ALOX5TSHRALDH1A1TDP1KMT2A | |
| SCHEMBL10594948 | 0.84 | KDM5A (0.44) | ALOX5TSHRALDH1A1TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161904-B1 | TETRAHYDROFURANYL AND TETRAHYDROTHIENYL SUBSTITUTED ETHERS | E.R. Squibb & Sons, Inc. (US) | 1989-10-18 | — | — | EP | disclosed |
| EP-0161904-A2 | Tetrahydrofuranyl and tetrahydrothienyl substituted ethers | E.R. Squibb & Sons, Inc. (US) | 1985-11-21 | — | — | EP | disclosed |
| US-4521539-A | ANALGESICS, CARDIONVASCULAR AND ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1985-06-04 | — | — | US | disclosed |