Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10595368 | 0.81 | DAO (0.45) | DAOTSHRLMNAMMP13PTGDR2 | |
| SCHEMBL10595363 | 0.81 | DAO (0.45) | DAOTSHRLMNAMMP13PTGDR2 | |
| SCHEMBL10865616 | 0.80 | TSHR (0.47) | DAOTSHRLMNAMMP13PTGDR2 | |
| SCHEMBL10596975 | 0.79 | DAO (0.43) | DAOTSHRLMNAMMP13PTGDR2 | |
| SCHEMBL10596968 | 0.79 | DAO (0.43) | DAOTSHRLMNAMMP13PTGDR2 | |
| SCHEMBL10595360 | 0.78 | DAO (0.51) | DAOTSHRLMNAMMP13PTGDR2 | |
| SCHEMBL10596953 | 0.77 | DAO (0.50) | DAOTSHRLMNAMMP13PTGDR2 | |
| SCHEMBL10595807 | 0.76 | DAO (0.49) | DAOTSHRPTGDR2MAPK1CYP3A4 | |
| SCHEMBL10595197 | 0.74 | DAO (0.47) | DAOTSHRPTGDR2USP2CYP3A4 | |
| SCHEMBL10597054 | 0.72 | DAO (0.46) | DAOTSHRLMNAPTGDR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0168950-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-01-11 | — | — | EP | disclosed |
| US-4769386-A | Imidazolylthioalkenoic acids and -alkenols and leukotriene antagonistic composition containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1988-09-06 | — | — | US | disclosed |
| EP-0168950-A1 | Leukotriene antagonists | SMITHKLINE BECKMAN CORPORATION (US) | 1986-01-22 | — | — | EP | disclosed |