SCHEMBL10597386

SCHEMBL10597386

CCOC(=O)c1ccccc1Nc1cccc(C(F)(F)F)c1

nearest known ligand 0.71

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.71
CYP1A2 P05177 1/20 0.71
CYP2C9 P11712 1/20 0.71
CYP2C19 P33261 1/20 0.71
YAP1 P46937 1/20 0.65
TEAD4 Q15561 1/20 0.65
TEAD2 Q15562 1/20 0.65
RXFP1 Q9HBX9 6/20 0.64
CACNA1B Q00975 1/20 0.56
APBA1 Q02410 1/20 0.56
NPSR1 Q6W5P4 1/20 0.56
CDC25B P30305 4/20 0.55
CDC25A P30304 1/20 0.55
CDC25C P30307 1/20 0.55
MPO P05164 3/20 0.53
TAS2R14 Q9NYV8 1/20 0.53
AKR1C3 P42330 1/20 0.53
AKR1C2 P52895 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ufenamate SCHEMBL36095 0.89 CYP1A2 (0.72) LMNACYP1A2CYP2C9CYP2C19YAP1
Ufenamate SCHEMBL29376700 0.89 CYP1A2 (0.72) LMNACYP1A2CYP2C9CYP2C19YAP1
SCHEMBL6434867 0.88 RXFP1 (0.61) LMNACYP1A2CYP2C9CYP2C19YAP1
SCHEMBL9271694 0.87 RXFP1 (0.70) LMNACYP1A2CYP2C9CYP2C19YAP1
SCHEMBL13299181 0.87 LMNA (0.67) LMNACYP1A2CYP2C9CYP2C19YAP1
SCHEMBL12715082 0.87 LMNA (0.91) LMNACYP1A2CYP2C9CYP2C19YAP1
SCHEMBL11520753 0.86 LMNA (0.66) LMNACYP1A2CYP2C9CYP2C19YAP1
SCHEMBL22556586 0.86 CDC25B (0.56) LMNACYP1A2CYP2C9CYP2C19NPSR1
SCHEMBL10592753 0.86 LMNA (0.57) LMNACYP1A2CYP2C9CYP2C19YAP1
Colfenamate SCHEMBL2110641 0.86 LMNA (0.68) LMNACYP1A2CYP2C9CYP2C19YAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4594357-A Depot antiinflammatory agents TROPONWERKE GMBH & CO. (DE) 1986-06-10 US claimed
CN-119997813-A Emulsifiable concentrate with lactone-based solvent system 巴斯夫欧洲公司 2025-05-13 CN disclosed
CN-119110681-A Emulsifiable concentrate with (substituted) benzaldehyde-based solvent system 巴斯夫欧洲公司 2024-12-10 CN disclosed
EP-0130524-B1 DEPOT ANTIPHLOGISTICS Troponwerke GmbH & Co. KG (DE) 1989-08-23 EP disclosed
EP-0130524-A2 Depot antiphlogistics Troponwerke GmbH & Co. KG (DE) 1985-01-09 EP disclosed
US-4198431-A ANTIINFLAMMATORY HOKURIKU PHARMACEUTICAL CO., LTD. (JP) 1980-04-15 US disclosed
US-3953449-A ANALGESICS SYNTHELABO (FR) 1976-04-27 US disclosed