Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10598512 | 0.82 | NPC1 (0.56) | NPC1RAB9APAX8JAK2GRIN2D | |
| SCHEMBL8028077 | 0.81 | NPC1 (0.42) | NPC1RAB9APAX8JAK2LMNA | |
| SCHEMBL11490914 | 0.77 | L3MBTL1 (0.49) | TRPV1L3MBTL1TDP1KCNN4KCNA5 | |
| SCHEMBL4983976 | 0.77 | MEN1 (0.50) | NPC1RAB9APAX8JAK2CYP3A4 | |
| SCHEMBL5818143 | 0.76 | NPC1 (0.54) | TRPV1KCNN4KCNA5NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8194065 | 0.75 | GRIN2D (0.49) | NPC1RAB9APAX8JAK2CYP3A4 | |
| SCHEMBL10602308 | 0.75 | GRIN2D (0.60) | TRPV1L3MBTL1TDP1GRIN2DGRIN3B | |
| SCHEMBL14229682 | 0.74 | TP53 (0.56) | TRPV1L3MBTL1KCNN4KCNA5NPC1 | |
| SCHEMBL29253651 | 0.74 | TRPV1 (0.40) | TRPV1L3MBTL1TDP1KCNN4KCNA5 | |
| SCHEMBL10852573 | 0.73 | TRPV1 (0.44) | TRPV1L3MBTL1NPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116628-B1 | 1-ACYL-3-PYRIDYLMETHYLGUANIDINES AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-01-18 | — | — | EP | disclosed |
| EP-0116628-A4 | 1-ACYL-3-PYRIDYLMETHYLGUANIDINES AND THEIR USE AS ANTIHYPERTENSIVE AGENTS. | RORER INTERNAT OVERSEAS INC (US) | 1985-02-18 | — | — | EP | disclosed |
| EP-0116628-A4 | 1-ACYL-3-PYRIDYLMETHYLGUANIDINES AND THEIR USE AS ANTIHYPERTENSIVE AGENTS. | RORER INTERNAT OVERSEAS INC (US) | 1985-02-18 | — | — | EP | disclosed |
| US-4496573-A | 1-Pyridylmethyl-3-acyl guanidines | WILLIAM H. RORER, INC. (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0116628-A1 | 1-ACYL-3-PYRIDYLMETHYLGUANIDINES AND THEIR USE AS ANTIHYPERTENSIVE AGENTS. | RORER INT OVERSEAS (US) | 1984-08-29 | — | — | EP | disclosed |
| EP-0116628-A1 | 1-ACYL-3-PYRIDYLMETHYLGUANIDINES AND THEIR USE AS ANTIHYPERTENSIVE AGENTS. | RORER INT OVERSEAS (US) | 1984-08-29 | — | — | EP | disclosed |
| WO-1984000963-A1 | 1-ACYL-3-PYRIDYLGUANIDINES AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | RORER INT OVERSEAS (US) | 1984-03-15 | — | — | WO | disclosed |
| WO-1984000963-A1 | 1-ACYL-3-PYRIDYLGUANIDINES AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | RORER INT OVERSEAS (US) | 1984-03-15 | — | — | WO | disclosed |