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SCHEMBL10597992

SCHEMBL10597992

CC(C)C[C@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)NC(=O)c1ccc(Cl)cc1

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ REN P00797 19/20 0.49
▸ CTSD P07339 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10602514 0.95 REN (0.53) REN
SCHEMBL10598154 0.92 REN (0.52) REN
SCHEMBL10598636 0.89 REN (0.53) REN
SCHEMBL8894705 0.89 REN (0.58) REN
SCHEMBL7311362 0.88 REN (0.55) REN
SCHEMBL7313266 0.88 REN (0.54) REN
SCHEMBL7316500 0.86 REN (0.53) REN
SCHEMBL10728504 0.86 REN (0.47) RENCTSD
SCHEMBL7316898 0.86 REN (0.52) REN
SCHEMBL7309673 0.85 REN (0.51) REN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0081783-B2 RENIN INHIBITORY PEPTIDES HAVING PHE 13 DELETION MERCK & CO. INC. (US) 1989-02-08 — — EP claimed
EP-0081783-B1 RENIN INHIBITORY PEPTIDES HAVING PHE 13 DELETION MERCK & CO. INC. (US) 1985-06-19 — — EP claimed
EP-0081783-A1 Renin inhibitory peptides having Phe 13 deletion MERCK & CO. INC. (US) 1983-06-22 — — EP claimed
EP-0081783-B2 RENIN INHIBITORY PEPTIDES HAVING PHE 13 DELETION MERCK & CO. INC. (US) 1989-02-08 — — EP disclosed
EP-0081783-B1 RENIN INHIBITORY PEPTIDES HAVING PHE 13 DELETION MERCK & CO. INC. (US) 1985-06-19 — — EP disclosed
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