SCHEMBL10598053

COC(=O)CCC(=O)O[C@]1(C(=O)CO)[C@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C

nearest known ligand 0.87

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1	P04150	15/20	0.85

▸	PGR	P06401	3/20	0.85

▸	MEN1	O00255	1/20	0.85

▸	USP2	O75604	1/20	0.85

▸	CYP3A4	P08684	1/20	0.85

▸	KMT2A	Q03164	1/20	0.85

▸	MMP1	P03956	14/20	0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL10599371	1.00	NR3C1 (0.85)	NR3C1PGRMEN1USP2CYP3A4
SCHEMBL10599514	1.00	NR3C1 (0.85)	NR3C1PGRMEN1USP2CYP3A4
SCHEMBL10600613	0.94	NR3C1 (0.75)	NR3C1PGRMEN1USP2CYP3A4
SCHEMBL10859143	0.94	NR3C1 (0.75)	NR3C1PGRMEN1USP2CYP3A4
SCHEMBL10859136	0.94	NR3C1 (0.75)	NR3C1PGRMEN1USP2CYP3A4
SCHEMBL1530976	0.94	NR3C1 (0.85)	NR3C1PGRMEN1USP2CYP3A4
SCHEMBL10598160	0.93	NR3C1 (0.84)	NR3C1PGRMEN1USP2CYP3A4
SCHEMBL10598077	0.93	NR3C1 (0.84)	NR3C1PGRMEN1USP2CYP3A4
SCHEMBL10600770	0.93	NR3C1 (0.84)	NR3C1PGRMEN1USP2CYP3A4
SCHEMBL10600554	0.93	NR3C1 (0.84)	NR3C1PGRMEN1USP2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0136586-B1	NOVEL CORTICOID DERIVATIVES AND PROCESS FOR PRODUCTION THEREOF	MITSUBISHI KASEI CORPORATION (JP)	1989-03-01	—	—	EP	disclosed
US-4602009-A	Corticoid derivatives and process for production thereof	MITSUBISHI CHEMICAL INDUSTRIES, LTD. (JP)	1986-07-22	—	—	US	disclosed