Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 5/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1058592 | 0.85 | HTR2C (0.37) | CHRM3HTR2CCYP2C19KDM1ASLC6A4 | |
| SCHEMBL935945 | 0.81 | OPRL1 (0.37) | CHRM3HTR2CHTR2AKDM1ASLC6A4 | |
| SCHEMBL1059129 | 0.78 | SLC6A2 (0.46) | HTR2CCYP2D6SLC6A4HTR2BHPGD | |
| SCHEMBL1059551 | 0.75 | SLC6A2 (0.47) | HTR2CCYP2D6SLC6A4HTR2BKCNH2 | |
| SCHEMBL935942 | 0.74 | SLC6A4 (0.44) | HTR2CSLC6A4HTR2BHPGDALDH1A1 | |
| SCHEMBL1054990 | 0.73 | SLC6A2 (0.46) | CHRM3HTR2CCYP2D6SLC6A4HTR2B | |
| SCHEMBL935109 | 0.73 | SLC6A2 (0.38) | HTR2CCYP2D6SLC6A4HTR2BKCNH2 | |
| SCHEMBL1054924 | 0.73 | SLC6A4 (0.43) | HTR2CHTR2ACYP2D6SLC6A4HTR2B | |
| SCHEMBL1054627 | 0.72 | SLC6A2 (0.43) | HTR2ACYP2D6SLC6A4HTR2BSLC6A2 | |
| SCHEMBL1059607 | 0.72 | SLC6A2 (0.33) | HTR2CHTR2ACYP2D6SLC6A4HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454234-B1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2018-04-11 | — | — | EP | disclosed |
| US-9227933-B2 | 3-phenoxymethylpyrrolidine compounds | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2016-01-05 | — | — | US | disclosed |
| US-20150126577-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-05-07 | — | — | US | disclosed |
| US-20110257243-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| US-7994209-B2 | 3-phenoxymethylpyrrolidine compounds | THERAVANCE, INC. (US) | 2011-08-09 | — | — | US | disclosed |
| US-20110009465-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE BIOPHARMA R&D IP, LLC | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150126577-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | HTR6, SLC6A4, SLC6A2 | CHRM3 70/4885HTR2C 31/4885HTR2A 48/4885 |
| US-20110009465-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | HTR6, SLC6A4, SLC6A2 | CHRM3 70/4885HTR2C 31/4885HTR2A 48/4885 |
| US-20110257243-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | HTR6, SLC6A4, SLC6A2 | CHRM3 70/4885HTR2C 31/4885HTR2A 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.