Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8837021 | 0.77 | ALDH1A1 (0.47) | ALDH1A1TSHRHTTMAPK1KMT2A | |
| SCHEMBL9308834 | 0.76 | CES1 (0.41) | ALDH1A1MAPK1KMT2AMEN1CES1 | |
| Water SCHEMBL1986090 | 0.76 | ALDH1A1 (0.46) | ALDH1A1TSHRHTTMAPK1KMT2A | |
| SCHEMBL11775673 | 0.74 | ALDH1A1 (0.57) | ALDH1A1TSHRHTTMAPK1KMT2A | |
| SCHEMBL530424 | 0.73 | ALDH1A1 (0.51) | ALDH1A1TSHRHTTKMT2ASMN1; SMN2 | |
| SCHEMBL7307357 | 0.71 | ALDH1A1 (0.42) | ALDH1A1TSHRHTTMAPK1KMT2A | |
| SCHEMBL28706287 | 0.71 | ALDH1A1 (0.42) | ALDH1A1TSHRHTTMAPK1KMT2A | |
| SCHEMBL11779225 | 0.71 | ALDH1A1 (0.50) | ALDH1A1TSHRHTTKMT2ASMN1; SMN2 | |
| SCHEMBL11091632 | 0.70 | CES1 (0.53) | ALDH1A1TSHRHTTKMT2ASMN1; SMN2 | |
| SCHEMBL3999764 | 0.70 | ALDH1A1 (0.67) | ALDH1A1TSHRHTTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4675400-A | FORM CONJUGATES WITH IMMUNOGLOBULINS; ANTITUMOR AGENTS | ELI LILLY AND COMPANY (US) | 1987-06-23 | — | — | US | claimed |
| EP-0153151-B1 | TRANSFERRIN-VINCA ALKALOID CYTOTOXIC COMPOSITIONS | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |
| EP-0153151-A2 | Transferrin-vinca alkaloid cytotoxic compositions | ELI LILLY AND COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |
| US-4522750-A | Cytotoxic compositions of transferrin coupled to vinca alkaloids | ELI LILLY AND COMPANY (US) | 1985-06-11 | — | — | US | disclosed |