Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10601007 | 0.95 | HCN4 (0.56) | HCN4MAPTKCNH2CYP3A4ALOX15 | |
| SCHEMBL10598819 | 0.91 | HCN4 (0.52) | HCN4MAPTKCNH2CYP3A4ALOX15 | |
| SCHEMBL10601090 | 0.87 | HCN4 (0.58) | HCN4MAPTKCNH2CYP3A4ALOX15 | |
| SCHEMBL11081464 | 0.86 | HCN4 (0.54) | HCN4MAPTKCNH2CYP3A4ALOX15 | |
| SCHEMBL10598410 | 0.85 | HCN4 (0.55) | HCN4MAPTKCNH2CYP3A4ALOX15 | |
| SCHEMBL10598451 | 0.85 | HCN4 (0.57) | HCN4MAPTKCNH2CYP3A4ALOX15 | |
| SCHEMBL10599844 | 0.83 | MAPT (0.53) | HCN4MAPTKCNH2CYP3A4ALOX15 | |
| SCHEMBL11096232 | 0.83 | HCN4 (0.67) | HCN4MAPTKCNH2CYP3A4ALOX15 | |
| SCHEMBL10601193 | 0.82 | HCN4 (0.67) | HCN4MAPTKCNH2CYP3A4ALOX15 | |
| SCHEMBL10600124 | 0.80 | GAA (0.36) | HCN4MAPTKCNH2CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109636-B1 | BENZAZEPINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1989-01-18 | — | — | EP | disclosed |
| US-4490369-A | HYPOTENSIVE, BRRADYCARDIAL | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-12-25 | — | — | US | disclosed |
| EP-0109636-A2 | Benzazepine derivatives, process for their preparation and their use as pharmaceutical compounds | Dr. Karl Thomae GmbH (DE) | 1984-05-30 | — | — | EP | disclosed |