SCHEMBL10600446

SCHEMBL10600446

c1ncc2ncn(C3CCCCC3)c2n1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 4/20 0.53
PI4KA P42356 3/20 0.53
PI4K2B Q8TCG2 3/20 0.53
PI4K2A Q9BTU6 3/20 0.53
PI4KB Q9UBF8 3/20 0.53
ADORA3 P0DMS8 2/20 0.50
ADORA1 P30542 2/20 0.50
ADORA2B P29275 1/20 0.46
HCAR1 Q9BXC0 5/20 0.43
AURKA O14965 1/20 0.43
JAK2 O60674 1/20 0.43
PRKCA P17252 1/20 0.43
JAK1 P23458 1/20 0.43
KDR P35968 1/20 0.43
JAK3 P52333 1/20 0.43
CYP1A2 P05177 2/20 0.42
CYP3A4 P08684 2/20 0.42
NFKB1 P19838 1/20 0.42
THPO P40225 1/20 0.42
BLM P54132 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2951838 0.98 ADORA2A (0.51) ADORA2API4KAPI4K2BPI4K2API4KB
Hydrochloric Acid SCHEMBL6821629 0.97 ADORA2A (0.50) ADORA2API4KAPI4K2BPI4K2API4KB
SCHEMBL1375991 0.95 ADORA2A (0.51) ADORA2API4KAPI4K2BPI4K2API4KB
SCHEMBL19553770 0.91 ADORA2A (0.49) ADORA2API4KAPI4K2BPI4K2API4KB
SCHEMBL20547471 0.79 CYP2C19 (0.54) ADORA2API4KAPI4K2BPI4K2API4KB
SCHEMBL4373722 0.78 SRC (0.40) ADORA2API4KAPI4K2BPI4K2API4KB
Hydrochloric Acid SCHEMBL7659251 0.77 ABL1 (0.39) ADORA2AHCAR1JAK2PRKCAKDR
Hydrochloric Acid SCHEMBL7843046 0.77 ABL1 (0.39) ADORA2AHCAR1JAK2PRKCAKDR
Hydrochloric Acid SCHEMBL7659259 0.77 ABL1 (0.39) ADORA2AHCAR1JAK2PRKCAKDR
Hydrochloric Acid SCHEMBL7659256 0.77 ABL1 (0.39) ADORA2AHCAR1JAK2PRKCAKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119384510-A Method for converting human somatic cells into proliferating neural stem cells 高丽大学校产学协力团 2025-01-28 CN disclosed
EP-3452477-B1 ADENINE DERIVATIVES AS PROTEIN KINASE INHIBITORS B C I PHARMA (BE) 2023-09-13 EP disclosed
CN-116368220-A Closed manufacturing process for large-scale production of pluripotent stem cell-derived cells 诺卡迪亚有限公司 2023-06-30 CN disclosed
WO-2022080473-A1 NERVE CELL ACTIVATOR 三沢幸子 2022-04-21 WO disclosed
CN-109311882-B Adenine derivatives as protein kinase inhibitors BCI制药公司 2022-02-11 CN disclosed
US-11236093-B2 Adenine derivatives as protein kinase inhibitors B.C.I. PHARMA (BE) 2022-02-01 US disclosed
CN-112055738-B Freezing point depression cycle control system, method and device 再合科技有限公司 2021-07-13 CN disclosed
CN-112055738-A Freezing point depression cycle control system, method and device 再合科技有限公司 2020-12-08 CN disclosed
US-20190127379-A1 ADENINE DERIVATIVES AS PROTEIN KINASE INHIBITORS B.C.I. PHARMA (BE) 2019-05-02 US disclosed
EP-3452477-A1 ADENINE DERIVATIVES AS PROTEIN KINASE INHIBITORS B.C.I. Pharma (BE) 2019-03-13 EP disclosed
CN-109311882-A adenine derivatives as protein kinase inhibitors BCI制药公司 2019-02-05 CN disclosed
WO-2017191297-A1 ADENINE DERIVATIVES AS PROTEIN KINASE INHIBITORS BCI PHARMA (FR) 2017-11-09 WO disclosed
CN-1013448-B N6Process for producing-substituted deoxyriboadenosine analogues WARNER LAMBERT CO (US) 1991-08-07 CN disclosed
EP-0181129-B1 N6-SUBSTITUTED DEOXYRIBOSE ANALOGS OF ADENOSINES WARNER-LAMBERT COMPANY (US) 1989-03-08 EP disclosed
CN-85108658-A N 6The manufacture method that replaces ribodesose adenyhomotype thing 1986-07-16 CN disclosed
EP-0181129-A2 N6-substituted deoxyribose analogs of adenosines WARNER-LAMBERT COMPANY (US) 1986-05-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11236093-B2 Adenine derivatives as protein kinase inhibitors ADK, TNNI3K, TNK2 ADORA2A 195/4885PI4KA 321/4885PI4K2B 659/4885
US-20190127379-A1 ADENINE DERIVATIVES AS PROTEIN KINASE INHIBITORS ADK, TNNI3K, TNK2 ADORA2A 195/4885PI4KA 321/4885PI4K2B 659/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.