ADK — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL91053	0.59	18/20
SCHEMBL810187	0.76	17/20
SCHEMBL68579	0.56	17/20
Iodotubercidin (SCHEMBL319225)	0.83	16/20
SCHEMBL59535	0.53	15/20
SCHEMBL887466	0.52	15/20
SCHEMBL60684	0.67	14/20
SCHEMBL67029	0.67	14/20
SCHEMBL90990	0.67	14/20
SCHEMBL60676	0.60	14/20
SCHEMBL67726	0.60	14/20
SCHEMBL90988	0.60	14/20
SCHEMBL67738	0.55	14/20
SCHEMBL90991	0.55	14/20
SCHEMBL783019	0.51	13/20
Sangivamycin (SCHEMBL195540)	0.72	12/20
SCHEMBL887898	0.58	12/20
SCHEMBL398109	0.57	12/20
SCHEMBL398110	0.57	12/20
SCHEMBL398720	0.57	12/20

Clinical trials — most relevant to ADK by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity	PHASE4	COMPLETED
Alpha Ketoglutarate Enhances Geroprotection In Surgery (AEGIS)	PHASE4	RECRUITING
Acelarin First Line Randomised Pancreatic Study	PHASE2/PHASE3	SUSPENDED
Preventing Acute Kidney Injury (AKI) in Pediatric Patients	PHASE3	UNKNOWN
Ticagrelor And PrEconditioning in Patients With coronaRy Artery diSease	PHASE2/PHASE3	COMPLETED
Study to Investigate the Effect of PBF-680 on Forced Expiratory Volume in 1 Second (FEV1) in Asthmatic Patients	PHASE2	COMPLETED
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Safety and Feasibility of Metformin for Sepsis Induced AKI	PHASE2	COMPLETED
A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations	PHASE1/PHASE2	RECRUITING
The Effect of Addition of Metformin In Obese Non- Diabetic Patients With Heart Failure With Preserved Ejection Fraction	PHASE2	UNKNOWN
8-Chloroadenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia	PHASE1/PHASE2	COMPLETED
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer	EARLY_PHASE1	COMPLETED
A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients	EARLY_PHASE1	RECRUITING
Cardiac and Skeletal Muscle Energy Metabolism in Abnormal Growth Hormone States	nan	COMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Poor Sleep and Inflammation in HIV-Infected Adults	nan	COMPLETED
Observational Study Evaluating the Prevalence of Enzyme Deficiency in Pulmonology Clinics (ADA)	nan	UNKNOWN
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
Prevalence of Adenosine Deaminase (ADA) Enzyme Deficiency Disease in Adult Patients With Pulmonary Alveolar Proteinosis	nan	UNKNOWN
Evaluation of Thymidine Kinase Activity in the Serum of Patients With Solid Tumors	nan	UNKNOWN
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction	nan	COMPLETED
Exercise in Type 1 Diabetes Mellitus	nan	COMPLETED
Metformine as a Protective Factor of Mortality in Type 2 Diabetic Patients Admitted to the ICU for Septic Shock.	nan	COMPLETED
Effect of Metformin on Chronic Pain After Thoracic Surgery in Diabetic Patients	nan	UNKNOWN
Expression of AMP-activated Protein Kinase (AMPK) Protein in Lung Adenocarcinoma	nan	UNKNOWN
Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia	nan	COMPLETED
Avapritinib in the Treatment of Unresectable or Recurrent Metastatic GIST Non-exon18 Mutations of PDGFRA	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a ADK binder may also engage these)

Protein	Name	Similarity
Q64640	—	1.000	Q64640 →
P55262	—	1.000	P55262 →
P55264	—	1.000	P55264 →
O49923	—	0.996	O49923 →
Q9SF85	—	0.986	Q9SF85 →
P78825	—	0.981	P78825 →
Q9LZG0	—	0.978	Q9LZG0 →
P47143	—	0.975	P47143 →
Q54MB5	—	0.973	Q54MB5 →
P46794	—	0.970	P46794 →
O93919	—	0.970	O93919 →
Q6XZ78	—	0.969	Q6XZ78 →
P34517	—	0.969	P34517 →
E3XDZ8	—	0.968	E3XDZ8 →
Q42954	—	0.968	Q42954 →
Q5XHY5	—	0.968	Q5XHY5 →
F1Q575	—	0.968	F1Q575 →
Q3T0C2	—	0.968	Q3T0C2 →
M2VWL5	—	0.967	M2VWL5 →
SGPL1	Sphingosine-1-phosphate lyase 1	0.967	landscape →
Q5RA68	—	0.967	Q5RA68 →
Q9QUJ7	—	0.967	Q9QUJ7 →
P03958	—	0.966	P03958 →
A4FUZ6	—	0.966	A4FUZ6 →
O94347	—	0.966	O94347 →
Q8R0X7	—	0.966	Q8R0X7 →
Q9CZW4	—	0.966	Q9CZW4 →
Q42586	—	0.966	Q42586 →
Q9SEE5	—	0.966	Q9SEE5 →
Q1PCB1	—	0.966	Q1PCB1 →