Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | METAP2 | P50579 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CNR1 | P21554 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19747534 | 0.81 | NPC1 (0.60) | NPC1EPHX1RAB9AP2RX7KMT2A | |
| SCHEMBL6175361 | 0.81 | NPC1 (0.61) | NPC1EPHX1RAB9AP2RX7KMT2A | |
| SCHEMBL5259572 | 0.81 | NPC1 (0.60) | NPC1EPHX1RAB9AP2RX7KMT2A | |
| SCHEMBL13162648 | 0.79 | NPC1 (0.59) | NPC1RAB9AP2RX7KMT2A | |
| SCHEMBL10521270 | 0.77 | ALDH1A1 (0.67) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL25123079 | 0.76 | SMN1; SMN2 (0.76) | NPC1EPHX1RAB9AKMT2AMEN1 | |
| SCHEMBL4522241 | 0.76 | SMN1; SMN2 (0.76) | NPC1EPHX1RAB9AKMT2AMEN1 | |
| SCHEMBL8395225 | 0.76 | SMN1; SMN2 (0.76) | NPC1EPHX1RAB9AKMT2AMEN1 | |
| SCHEMBL6355637 | 0.75 | NPC1 (0.60) | NPC1EPHX1RAB9AP2RX7KMT2A | |
| SCHEMBL10521115 | 0.75 | ALDH1A1 (0.64) | NPC1METAP2RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0198277-B1 | DISELENO-BIS-BENZAMIDES OF PRIMARY AND SECONDARY AMINES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | A. Nattermann & Cie. GmbH (DE) | 1989-05-03 | — | — | EP | disclosed |